Cullen K J, Knuiman M W, Ward N J
Health Centre, Busselton, Western Australia.
Am J Epidemiol. 1993 Jan 15;137(2):242-8. doi: 10.1093/oxfordjournals.aje.a116665.
The authors analyzed 23-year mortality (1966-1989) in 2,171 subjects aged > or = 40 years from a Busselton, Western Australia, prospective study. The analysis revealed significant inverse associations between alcohol consumption and mortality, with trends of decreasing mortality shown from nondrinkers to mild drinkers to moderate drinkers. Compared with nondrinkers, moderate drinkers had an adjusted relative risk of death due to all causes of 0.76 (95% confidence interval (CI) 0.61-0.94). The adjusted relative risk of cardiovascular disease death among moderate drinkers was 0.68 (95% CI 0.51-0.91), and that of coronary heart disease death was 0.66 (95% CI 0.45-0.98). Adjustment for baseline coronary disease risk factors strengthened these trends in the relative risks observed in both women and men. Baseline and follow-up data suggested that 87% of the nondrinkers were long-term abstainers, with 77% having been such for a lifetime.
作者分析了西澳大利亚州巴瑟尔顿一项前瞻性研究中2171名年龄≥40岁受试者的23年死亡率（1966 - 1989年）。分析显示，饮酒与死亡率之间存在显著的负相关，从不饮酒者到轻度饮酒者再到中度饮酒者，死亡率呈下降趋势。与不饮酒者相比，中度饮酒者因各种原因导致的死亡调整后相对风险为0.76（95%置信区间（CI）0.61 - 0.94）。中度饮酒者中心血管疾病死亡的调整后相对风险为0.68（95%CI 0.51 - 0.91），冠心病死亡的调整后相对风险为0.66（95%CI 0.45 - 0.98）。对基线冠心病危险因素进行调整后，男女中观察到的相对风险趋势均得到加强。基线和随访数据表明，87%的不饮酒者为长期戒酒者，其中77%终生戒酒。
