Bora P S, Lange L G
Department of Medicine, Jewish Hospital of St. Louis, Washington University Medical Center, MO 63110.
Alcohol Clin Exp Res. 1993 Feb;17(1):28-30. doi: 10.1111/j.1530-0277.1993.tb00721.x.
Ethanol metabolism in the human brain has been documented to occur with the formation of fatty acid ethyl esters. These neutral lipids can disorder membranes and interrupt mitochondrial function. Their formation is under the control of three synthases, localized to grey matter and purified to homogeneity. cDNA cloning demonstrates two of these enzymes to be GSH S-transferases and has enabled initiation of genetic studies of alcohol-induced CNS injury.
人类大脑中的乙醇代谢过程已被证实会伴随着脂肪酸乙酯的形成。这些中性脂质会扰乱细胞膜并破坏线粒体功能。它们的形成受三种合酶的控制，这些合酶定位于灰质且已被纯化至同质状态。cDNA克隆显示其中两种酶是谷胱甘肽S-转移酶，这使得酒精诱导的中枢神经系统损伤的基因研究得以启动。
