Dholakia N, Rolston K V, Ho D H, LeBlanc B, Bodey G P
Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Antimicrob Agents Chemother. 1994 Apr;38(4):848-52. doi: 10.1128/AAC.38.4.848.
The antibacterial activity of levofloxacin was compared with those of ofloxacin and ciprofloxacin against bacterial isolates from patients with cancer. In general, levofloxacin was as active or was twofold more active than ofloxacin and was two- to fourfold less active than ciprofloxacin against most gram-negative pathogens. Against Pseudomonas aeruginosa, ciprofloxacin was the most active agent tested (MIC for 90% of isolates tested, 1.0 microgram/ml). Overall, all three agents had similar activities against gram-positive organisms and were moderately active against methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci, Streptococcus species, and Enterococcus species.
将左氧氟沙星与氧氟沙星和环丙沙星对癌症患者分离出的细菌的抗菌活性进行了比较。总体而言,左氧氟沙星对大多数革兰氏阴性病原体的活性与氧氟沙星相当或比其高两倍,而比环丙沙星低两至四倍。对于铜绿假单胞菌,环丙沙星是测试的最具活性的药物(90%测试分离株的 MIC 为 1.0 微克/毫升)。总体而言,这三种药物对革兰氏阳性菌的活性相似,对甲氧西林敏感的金黄色葡萄球菌、凝固酶阴性葡萄球菌、链球菌属和肠球菌属有中等活性。