Miyamoto O, Itano T, Yamamoto Y, Tokuda M, Matsui H, Janjua N A, Suwaki H, Okada Y, Murakami T H, Negi T
Dept of Physiology, Kagawa Medical School, Japan.
Brain Res. 1993 Feb 12;603(1):143-7. doi: 10.1016/0006-8993(93)91312-g.
Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.
将胚胎神经组织移植到先前已点燃的大鼠体内。将13至14天的胚胎海马细胞悬液移植到海马CA2区附近的海马原层。几乎80%的动物恢复良好且不再发作。注射新皮质细胞或生理盐水对点燃易感性没有任何积极影响。虽然20天胚胎细胞移植也有效，但其效果不如13至14天胚胎移植持久。这些观察结果表明，神经移植可能用于治疗药物难治性癫痫。
