低剂量阿司匹林降低实验性主动脉瓣心内膜炎中的细菌滴度
Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis.
作者信息
Nicolau D P, Freeman C D, Nightingale C H, Quintiliani R, Coe C J, Maderazo E G, Cooper B W
机构信息
Department of Pharmacy, Hartford Hospital, Connecticut 06115.
出版信息
Infect Immun. 1993 Apr;61(4):1593-5. doi: 10.1128/iai.61.4.1593-1595.1993.
Abstract
Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.
摘要
利用金黄色葡萄球菌心内膜炎兔模型，我们研究了阿司匹林对这种感染自然病程的影响。与未治疗的动物相比，接受阿司匹林治疗的动物赘生物重量降低了30%（P = 0.11），赘生物细菌滴度降低了84%（P = 0.03）。
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