Schwinger R H, Böhm M, Koch A, Uhlmann R, Uberfuhr P, Kreuzer E, Reichart B, Erdmann E
Universität München, Medizinische Klinik I, München, Germany.
Mol Cell Biochem. 1993 Feb 17;119(1-2):73-8. doi: 10.1007/BF00926856.
In human heart failure, an increase in frequency of stimulation is followed by a reduced force of contraction in vivo and in vitro. The present study aimed to investigate whether a different origin of the myocardial sample or pretreatment with the cardioprotective agent 2,3-butanedione-monoxime (BDM) influences the force-frequency-relationship in electrically driven muscle strips taken from failing and nonfailing human myocardium. With as well as without pretreatment with BDM, the altered force-frequency-relationship in failing compared to nonfailing human ventricular myocardium can be observed. The effectiveness and the potency to increase force of contraction following an increase in frequency of stimulation was significantly higher in atrial than in ventricular myocardium in nonfailing and failing tissue. The different observations in atrial and ventricular myocardium provide evidence for functionally relevant differences in the electromechanical coupling between the human atrial and ventricular myocardium.
在人类心力衰竭中，刺激频率增加后，体内和体外的收缩力都会降低。本研究旨在探讨心肌样本的不同来源或用心脏保护剂2,3-丁二酮单肟（BDM）预处理是否会影响取自衰竭和未衰竭人类心肌的电驱动肌肉条中的力-频率关系。无论是否用BDM预处理，与未衰竭的人类心室心肌相比，衰竭的人类心室心肌中力-频率关系的改变均可观察到。在未衰竭和衰竭组织中，心房心肌在刺激频率增加后增加收缩力的有效性和效力显著高于心室心肌。心房和心室心肌的不同观察结果为人类心房和心室心肌之间机电耦合的功能相关差异提供了证据。
