Isensee H, Rietz B, Jacob R
Institute of Physiology II, University of Tübingen, Fed. Rep. of Germany.
Arzneimittelforschung. 1993 Feb;43(2):94-8.
The influence of an intake of garlic powder (1%--corresponding to Kwai/Sapec--added to a standard chow for a 10-week period) on the susceptibility to ventricular arrhythmias under ischemia and reperfusion was investigated in the isolated rat heart (Langendorff preparation) perfused with a modified Krebs-Henseleit solution. The incidence of ventricular tachycardia (VT) and fibrillation (VF) after ligation of the descending branch of the left coronary artery (LAD) (20 min) was significantly reduced in the garlic group as compared to untreated controls (VT: 0% vs. 35.5%; VF: 50% vs. 88%). The size of the ischemic zone was significantly smaller (31.7% vs. 40.9% of total heart tissue). The reperfusion experiments (5 min after 10 min ischemia) revealed similar results (VT: 50% vs. 100%; VF: 30% vs. 90%). The time until occurrence of extrasystoles and VT or VF was prolonged in most cases, and the duration of arrhythmias was abbreviated. No significant alterations in cardiac membrane fatty acid composition could be found. Inhibition of cyclooxygenase by acetylsalicylic acid (ASA) caused a moderate increase in arrhythmias and ischemic zone in the garlic group as well as in untreated controls under the conditions of the present experiments. Thus, it seems that the prostaglandin system does not play a predominant role in the cardioprotective action of garlic. The significance of free radical scavenging activity of garlic for its antiarrhythmic effects has to be established.
研究了在改良的克雷布斯 - 亨泽莱特溶液灌注的离体大鼠心脏（兰根多夫制备法）中，摄入大蒜粉（1%——相当于葵蒜酯/萨佩克——添加到标准饲料中，持续10周）对缺血和再灌注时室性心律失常易感性的影响。与未处理的对照组相比，大蒜组在结扎左冠状动脉（LAD）降支（20分钟）后室性心动过速（VT）和颤动（VF）的发生率显著降低（VT：0%对35.5%；VF：50%对88%）。缺血区的大小显著更小（占全心组织的31.7%对40.9%）。再灌注实验（缺血10分钟后5分钟）显示了类似的结果（VT：50%对100%；VF：30%对90%）。在大多数情况下，早搏、VT或VF发生前的时间延长，且心律失常的持续时间缩短。未发现心脏膜脂肪酸组成有显著改变。在本实验条件下，阿司匹林（ASA）抑制环氧化酶导致大蒜组以及未处理对照组的心律失常和缺血区适度增加。因此，前列腺素系统似乎在大蒜的心脏保护作用中不发挥主要作用。大蒜的自由基清除活性对其抗心律失常作用的重要性有待确定。
