Sumper M, Berg E, Wenzl S, Godl K
Lehrstuhl Biochemie I, Universität Regensburg, Germany.
EMBO J. 1993 Mar;12(3):831-6. doi: 10.1002/j.1460-2075.1993.tb05723.x.
The sex-inducing pheromone of Volvox carteri is a glycoprotein that triggers development of males and females at a concentration below 10(-16) M. Evidence is presented for the existence of a novel mechanism of signal amplification operating within the extracellular matrix of this multicellular organism. A family of 70 kDa matrix glycoproteins denoted pherophorins bear a C-terminal domain being homologous to the sex-inducing pheromone. Under the influence of the pheromone, this domain is liberated by highly specific proteolysis.
团藻的性诱导信息素是一种糖蛋白,在浓度低于10^(-16) M时可触发雄性和雌性的发育。本文提供了证据,证明在这种多细胞生物的细胞外基质中存在一种新的信号放大机制。一类被称为信息素运载蛋白的70 kDa基质糖蛋白带有一个与性诱导信息素同源的C末端结构域。在信息素的影响下,该结构域通过高度特异性的蛋白水解作用被释放出来。