Coleman N, Speirs G, Khan J, Broadbent V, Wight D G, Warren R E
Department of Histopathology, Addenbrooke's Hospital, Cambridge.
J Clin Pathol. 1993 Feb;46(2):180-3. doi: 10.1136/jcp.46.2.180.
A 15 year old boy being treated for relapsed acute lymphoblastic leukaemia developed severe diarrhoea and abdominal pain which worsened despite empirical antibiotic treatment. A right hemicolectomy was performed. The caecum and ascending colon showed changes typical of neutropenic enterocolitis. Clostridium tertium was isolated from faeces, blood cultures, and from the resected gut wall, with no evidence of other organisms capable of causing such a condition. As far as is known, this is the first reported case in which neutropenic enterocolitis has been associated with well documented C tertium infection, an organism previously described as a cause of bacteraemia in neutropenic patients.
一名15岁的复发性急性淋巴细胞白血病男孩在接受治疗时出现了严重腹泻和腹痛，尽管接受了经验性抗生素治疗，症状仍不断恶化。随后进行了右半结肠切除术。盲肠和升结肠呈现出典型的中性粒细胞减少性小肠结肠炎的变化。从粪便、血培养以及切除的肠壁中分离出了第三梭状芽孢杆菌，未发现其他能够引发这种病症的生物体迹象。据所知，这是首例有充分记录表明中性粒细胞减少性小肠结肠炎与第三梭状芽孢杆菌感染相关的病例，该生物体此前被描述为中性粒细胞减少患者菌血症的病因。
