Kanis J A
Department of Human Metabolism, University of Sheffield, UK.
Osteoporos Int. 1993;3 Suppl 1:10-5. doi: 10.1007/BF01621853.
Fragility fractures are now recognized as a major public health problem. Although the prevalence of all fractures is similar among men and women, the vast majority of osteoporotic fractures occur in elderly women. These comprise vertebral compression fractures, Colles' fracture at the wrist and hip fracture, and to a lesser extent fractures at other sites. The fracture of greatest socioeconomic consequence in Europe is hip fracture, which increases exponentially in incidence with age. The reasons for differences in age- and sex-specific incidence relate in part to the lower bone density of women at the time of maturity (peak bone density) and the accelerated bone loss that occurs after the menopause. Women live significantly longer than men, so that the prevalence of osteoporosis amongst elderly women is six-fold that of men. The age-specific incidence of hip fracture is rising in men and women in many countries, and if the current trends in the United Kingdom continue then the number of hip fractures occurring each year will more than double over the next 20 years. There is a marked geographic distribution in the incidence of hip fractures, even in Europe. Indeed the differences in incidence between communities is greater than the differences in incidence between sexes within communities. This suggests that the importance of gonadal insufficiency in women has been overemphasized and that other factors, probably relating to genetic or lifestyle factors affecting peak bone density, account for ecological differences in incidence of hip fracture between communities.
脆性骨折现已被公认为一个重大的公共卫生问题。尽管所有骨折的患病率在男性和女性中相似,但绝大多数骨质疏松性骨折发生在老年女性身上。这些骨折包括椎体压缩性骨折、腕部的科雷氏骨折和髋部骨折,其他部位的骨折相对较少。在欧洲,社会经济后果最严重的骨折是髋部骨折,其发病率随年龄呈指数增长。年龄和性别特异性发病率差异的部分原因在于女性在成熟时(骨密度峰值)的骨密度较低,以及绝经后出现的骨质加速流失。女性的寿命明显长于男性,因此老年女性中骨质疏松症的患病率是男性的六倍。在许多国家,男性和女性髋部骨折的年龄特异性发病率都在上升,如果英国目前的趋势持续下去,那么在未来20年里每年发生的髋部骨折数量将增加一倍以上。即使在欧洲,髋部骨折的发病率也存在明显的地理分布差异。事实上,不同社区之间的发病率差异大于同一社区内不同性别之间的发病率差异。这表明女性性腺功能不全的重要性被过度强调了,其他因素,可能与影响骨密度峰值的遗传或生活方式因素有关,导致了不同社区之间髋部骨折发病率的生态差异。