Kirsner R S, Pardes J B, Eaglstein W H, Falanga V
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33136.
J Am Acad Dermatol. 1993 Apr;28(4):623-7. doi: 10.1016/0190-9622(93)70085-8.
Lipodermatosclerosis refers to the skin induration and hyperpigmentation of the legs that often occurs in patients who have venous insufficiency. Lipodermatosclerosis has also been termed hypodermitis sclerodermiformis and appears to be similar if not-identical to the recently described sclerosing panniculitis of the leg. There has been much confusion about the nature, clinical course, and treatment of lipodermatosclerosis. We believe that lipodermatosclerosis has an acute, inflammatory phase and a chronic, fibrotic stage, although a spectrum exists. Direct immunofluorescence studies of early and late lesions are helpful in that they show dermal pericapillary fibrin deposits without other immunoreactants. Treatment of lipodermatosclerosis consists of compression therapy with either graded stockings or elastic bandages. We and others have found that the anabolic steroid stanozolol improves this condition rapidly and consistently.
脂膜炎性硬化症是指腿部皮肤硬结和色素沉着过度，常见于静脉功能不全的患者。脂膜炎性硬化症也被称为硬皮病样皮下炎，与最近描述的腿部硬化性脂膜炎似乎相似，甚至相同。关于脂膜炎性硬化症的性质、临床病程和治疗存在很多混淆。我们认为脂膜炎性硬化症有急性期、炎症期和慢性纤维化期，尽管存在一个连续谱。对早期和晚期病变进行直接免疫荧光研究是有帮助的，因为它们显示真皮毛细血管周围有纤维蛋白沉积，而无其他免疫反应物。脂膜炎性硬化症的治疗包括使用分级弹力袜或弹性绷带进行压迫治疗。我们和其他人发现，合成代谢类固醇司坦唑醇能迅速且持续地改善这种情况。
