Péret Leonardo Amédée, Vidal Heloisa Malaquias, Gomes Gabriela Alves Cardoso, Oliveira Gabriel Victor Borba, Aguiar Lainara Magalhães
Universidade José do Rosário Vellano - UNIFENAS, Faculdade de Medicina, Belo Horizonte, MG, Brasil.
J Vasc Bras. 2019 Oct 30;18:e20190031. doi: 10.1590/1677-5449.190031.
Lipodermatosclerosis is a panniculitis characterized by hardening and hyperpigmentation of the skin involving the calves with an "inverted champagne bottle" appearance. Many therapeutic approaches have been recommended, but the use of oxandrolone for this purpose has been studied very little to date. We report a case of acute lipodermatosclerosis in a 61-year-old woman with a previous history of surgical treatment for venous insufficiency of the lower limbs. The patient presented with edema and painful, erythematous lesions with diffuse infiltration, mainly affecting the posterior aspect of the left calf. She was initially treated with stanozolol and pentoxifylline, with good response. Due to unavailability of stanozolol, she was put on oxandrolone. This treatment was well tolerated, reduced the intensity of edema, erythema, and infiltration in the lower limbs, effectively leading to pain relief. Oxandrolone may be a useful and safe treatment for patients with acute lipodermatosclerosis.
脂膜炎性硬化症是一种脂膜炎，其特征为累及小腿的皮肤硬化和色素沉着，呈现“倒香槟瓶”外观。目前已推荐了多种治疗方法，但迄今为止，氧雄龙用于此目的的研究非常少。我们报告一例61岁女性急性脂膜炎性硬化症病例，该患者既往有下肢静脉功能不全的手术治疗史。患者表现为水肿以及伴有弥漫性浸润的疼痛性红斑病变，主要累及左小腿后侧。她最初接受司坦唑醇和己酮可可碱治疗，反应良好。由于无法获得司坦唑醇，她改用氧雄龙治疗。该治疗耐受性良好，减轻了下肢水肿、红斑和浸润的程度，有效缓解了疼痛。氧雄龙可能是急性脂膜炎性硬化症患者一种有用且安全的治疗方法。
