艾芬地尔对促肾上腺皮质激素诱导的大鼠行为综合征的影响。

Influence of ifenprodil on the ACTH-induced behavioral syndrome in rats.

作者信息

Genedani S, Bernardi M, Bertolini A

机构信息

Institute of Pharmacology, University of Modena, Italy.

出版信息

Eur J Pharmacol. 1994 Jan 24;252(1):77-80. doi: 10.1016/0014-2999(94)90577-0.

DOI:10.1016/0014-2999(94)90577-0

PMID:8149997

Abstract

Ifenprodil--an antagonist at the modulatory site of the NMDA receptor complex sensitive to polyamines--intraperitoneally injected at doses of 3 or 10 mg/kg, dose dependently prevented the behavioral syndrome induced by intracerebroventricular administration of adrenocorticotropin (ACTH)-(1-24) in adult male rats (excessive grooming, stretching, yawning, penile erections). These data further support a role of the brain ornithine decarboxylase (ODC)-polyamine system in the ACTH-induced behavioral syndrome, and may suggest an involvement of excitatory amino acids.

摘要

ifenprodil（一种对多胺敏感的N-甲基-D-天冬氨酸（NMDA）受体复合物调节位点拮抗剂）以3或10毫克/千克的剂量腹腔注射，剂量依赖性地预防成年雄性大鼠脑室内注射促肾上腺皮质激素（ACTH）-（1-24）诱发的行为综合征（过度梳理毛发、伸展、打哈欠、阴茎勃起）。这些数据进一步支持脑鸟氨酸脱羧酶（ODC）-多胺系统在ACTH诱发的行为综合征中的作用，并可能提示兴奋性氨基酸的参与。