Wachnik A, Biró G, Biró L, Korom M, Gergely A, Antal M
Department of Food Biochemistry, National Research Institute of Mother and Child, Warsaw, Poland.
Nahrung. 1993;37(1):28-34. doi: 10.1002/food.19930370106.
Sex dependence of copper, zinc, iron nutritional status and hepatic lipid peroxidation was studied in gonadectomized, hormone substituted and sham-operated male and female rats. The experiment was performed on H-Wistar rats (106 +/- 10 g) fed conventional laboratory food ad libitum for 12 weeks. The estrogen dependence of copper status is fully confirmed by the results of this study. In hormonally active females the malondialdehyde production was depressed which is supposed to be connected with high copper and low triglyceride levels in the liver. The anaemia observed in estrogen substituted rats may be a result of lower lipid peroxidation rate. The levels of retinol and alkaline phosphatase activity in sera are probably influenced by estrogen action. It is suggested that testosterone leads to acceleration of lipid peroxidation.
在去势、激素替代及假手术的雄性和雌性大鼠中研究了铜、锌、铁营养状况及肝脏脂质过氧化的性别依赖性。实验选用体重为106±10克的H-Wistar大鼠，随意喂食常规实验室食物，持续12周。本研究结果充分证实了铜状态的雌激素依赖性。在具有激素活性的雌性大鼠中，丙二醛生成减少，这可能与肝脏中高铜和低甘油三酯水平有关。在雌激素替代大鼠中观察到的贫血可能是脂质过氧化率较低的结果。血清中视黄醇水平和碱性磷酸酶活性可能受雌激素作用的影响。有研究表明，睾酮会导致脂质过氧化加速。
