Wachnik A, Biró G, Biró L, Gergely A, Antal M
National Research Institute of Mother and Child, Warsaw, Poland.
Z Ernahrungswiss. 1992 Jun;31(2):103-9. doi: 10.1007/BF01623068.
The aim of this experiment was to study the interrelationships between nutritional status of chosen trace elements (Cu, Zn, Fe) and hepatic lipid peroxidation in streptozotocin-induced diabetic rats. Both copper accumulation and disruption of iron storage were observed in livers of diabetic rats. MDA 0' (baseline) and MDA 30' (produced) levels measured in the liver were negatively correlated with blood glucose levels. MDA 30' levels correlated positively with iron concentration in the liver. It is supposed that the hormonal lability during experimental diabetes caused changes in metabolism of trace elements, and subsequently influenced the rate of lipid peroxidation.
本实验的目的是研究链脲佐菌素诱导的糖尿病大鼠体内所选微量元素（铜、锌、铁）的营养状况与肝脏脂质过氧化之间的相互关系。在糖尿病大鼠的肝脏中观察到铜的蓄积和铁储存的破坏。肝脏中测得的丙二醛0'（基线）和丙二醛30'（产生量）水平与血糖水平呈负相关。丙二醛30'水平与肝脏中铁浓度呈正相关。据推测，实验性糖尿病期间的激素不稳定导致微量元素代谢发生变化，进而影响脂质过氧化速率。
