Hosoi Y, Sakamoto K
Department of Radiology, Tohoku University School of Medicine, Sendai, Japan.
Radiother Oncol. 1993 Feb;26(2):177-9. doi: 10.1016/0167-8140(93)90101-d.
The dose dependency and effective period of suppressive effects by low dose total body irradiation (TBI) in both artificial and spontaneous lung metastasis were investigated using murine squamous cell carcinoma. In the artificial lung metastasis of the tumour cells injected through a tail vein, the TBI of 0.15-0.20 Gy resulted in significant net suppression of lung colony formation. With this dose range, the effective period lasted for 12 h ranging from 9 h before to 3 h after the tumour cell injection. Similar suppressive effect was also observed in the spontaneous lung metastasis. These data suggest that careful assessment of effective dose and duration of low dose TBI on human metastasis could provide a new therapy to suppress clinical metastasis.
利用小鼠鳞状细胞癌，研究了低剂量全身照射（TBI）对人工和自发性肺转移抑制作用的剂量依赖性和有效期。在通过尾静脉注射肿瘤细胞的人工肺转移模型中，0.15-0.20 Gy的TBI导致肺集落形成显著净抑制。在此剂量范围内，有效期持续12小时，从肿瘤细胞注射前9小时至注射后3小时。在自发性肺转移中也观察到类似的抑制作用。这些数据表明，仔细评估低剂量TBI对人类转移的有效剂量和持续时间可为抑制临床转移提供一种新的治疗方法。
