Wong M, Edelstein J, Wollman J, Bond M G
Cardiology Section (WIIIE), West Los Angeles VAMC, CA 90073.
Arterioscler Thromb. 1993 Apr;13(4):482-6. doi: 10.1161/01.atv.13.4.482.
Recent intravascular ultrasound experience challenges the accuracy of ultrasonic measurement of arterial wall thickness. We reevaluated the correlation between histological and sonographic measurements of intima-media thickness using standard transcutaneous vascular technology. Carotid and femoral arterial segments were imaged before and after fixation using a 7-MHz linear-array vascular transducer. Log compression and beam orientation were varied. Mean intima, media, and adventitia thicknesses were measured and compared with corresponding histological tunica. Tissue processing caused 2.5% shrinkage. Intraobserver reading error was 0.7% for histology and 5.4% for sonography. Ultrasound overestimated the thickness of the intima and adventitia and underestimated the thickness of the media. For combined intima-media thickness, the differences between histology and imaging were insignificant, averaging 4% for the carotid artery and 9% for the femoral artery in the far-wall projection. In the near-wall projection, sonographic intima-media thickness was 20% less than that determined histologically. We conclude that ultrasonography is limited mainly by axial resolution in quantifying the dimensions of individual arterial tunica but is capable of accurately measuring far-wall intima-media thickness.
近期的血管内超声经验对动脉壁厚度超声测量的准确性提出了挑战。我们使用标准经皮血管技术重新评估了内膜中层厚度的组织学测量与超声测量之间的相关性。使用7兆赫线性阵列血管换能器在固定前后对颈动脉和股动脉节段进行成像。改变对数压缩和波束方向。测量平均内膜、中膜和外膜厚度，并与相应的组织学膜进行比较。组织处理导致2.5%的收缩。观察者内部读数误差在组织学方面为0.7%，在超声检查方面为5.4%。超声高估了内膜和外膜的厚度，低估了中膜的厚度。对于内膜中层厚度总和，组织学与成像之间的差异不显著，在远壁投影中，颈动脉平均为4%，股动脉为9%。在近壁投影中，超声测量的内膜中层厚度比组织学测定值少20%。我们得出结论，超声检查在量化单个动脉膜的尺寸时主要受轴向分辨率的限制，但能够准确测量远壁内膜中层厚度。
