Romano A G, Harvey J A
Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
Pharmacol Biochem Behav. 1993 Apr;44(4):965-9. doi: 10.1016/0091-3057(93)90032-o.
The behavioral effects of a single, acute dose of methylenedioxyamphetamine (MDA) were assessed using the rabbit nictitating membrane (NM) preparation. Acquisition of the classically conditioned NM response was carried out in a single session under MDA at doses of 10 and 20 mumol/kg (1.79 and 3.58 mg/kg, respectively) and retention was assessed during a drug-free state 48 h later. In agreement with previous reports, MDA at a dose of 10 mumol/kg enhanced acquisition of the conditioned NM response and learning was retained in the nondrug state. However, MDA at a dose of 20 mumol/kg failed to affect either acquisition or retention. In further agreement with previous reports, MDA at 10 mumol/kg facilitated the amplitude of the unconditioned response during unpaired stimulus presentations. It is suggested that this enhanced motor response may be due to enhanced neural transmission in the afferent limb of the unconditioned reflex arc.
使用兔瞬膜（NM）标本评估了单剂量急性亚甲二氧基苯丙胺（MDA）的行为效应。在单次实验中，以10和20 μmol/kg（分别为1.79和3.58 mg/kg）的剂量在MDA作用下进行经典条件反射性瞬膜反应的习得，并在48小时后的无药状态下评估记忆保持情况。与先前的报道一致，10 μmol/kg剂量的MDA增强了条件性瞬膜反应的习得，且在无药状态下记忆得以保持。然而，20 μmol/kg剂量的MDA对习得或记忆保持均无影响。与先前报道进一步一致的是，10 μmol/kg的MDA在非配对刺激呈现期间促进了非条件反应的幅度。提示这种增强的运动反应可能是由于非条件反射弧传入支中神经传递增强所致。
