Jones C J, Kuo L, Davis M J, Chilian W M
Basic Res Cardiol. 1993 Jan-Feb;88(1):2-10. doi: 10.1007/BF00788525.
We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primarily governing coronary blood flow. Further studies utilizing measurement of segmental coronary microvascular diameters in isolated microvessels and in the beating heart may elucidate the nature of these interactions. Clinical studies may determine whether reversal of endothelial impairment in the diseased coronary microcirculation contributes to autoregulatory vasodilation, increases resting myocardial perfusion, and increases the threshold for myocardial ischemia during exercise.
我们最近获得的证据表明，节段性冠状动脉微血管直径以及由此产生的阻力，受对压力和流量的肌源性及内皮反应控制。此外，完整心脏研究表明，这些机制可能与主要控制冠状动脉血流的代谢机制存在重要相互作用。利用分离微血管和跳动心脏中节段性冠状动脉微血管直径测量的进一步研究，可能会阐明这些相互作用的本质。临床研究可以确定，患病冠状动脉微循环中内皮功能障碍的逆转是否有助于自动调节性血管舒张、增加静息心肌灌注以及提高运动期间心肌缺血的阈值。
