烧伤患者血浆肿瘤坏死因子-α（TNF-α）水平

Plasma tumour necrosis factor-alpha (TNF-alpha) levels in patients with burns.

作者信息

Endo S, Inada K, Yamada Y, Kasai T, Takakuwa T, Nakae H, Kikuchi M, Hoshi S, Suzuki M, Yamashita H

机构信息

Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

出版信息

Burns. 1993 Apr;19(2):124-7. doi: 10.1016/0305-4179(93)90033-5.

DOI:10.1016/0305-4179(93)90033-5

PMID:8471144

Abstract

Levels of plasma tumour necrosis factor-alpha (TNF-alpha) were determined consecutively in 42 patients with burns > 20 per cent of the total body surface area using an enzyme-linked immunosorbent assay. In the early period after injury (including the period of burn shock), 24 patients had detectable TNF-alpha levels in their plasma. However, the plasma TNF-alpha levels at the time of admission were very low and did not correlate with the extent of the burn or the prognosis. In contrast, the maximum plasma TNF-alpha level over the whole clinical course was significantly correlated with the area of the burn and the prognosis. No correlation was found between the plasma TNF-alpha and plasma endotoxin levels. TNF-alpha may be produced locally in infected burns and monitoring of plasma TNF-alpha levels may be a useful prognostic indicator for burns patients.

摘要

采用酶联免疫吸附测定法，对42例烧伤面积超过体表面积20%的患者连续测定血浆肿瘤坏死因子-α（TNF-α）水平。在受伤后的早期（包括烧伤休克期），24例患者血浆中可检测到TNF-α水平。然而，入院时血浆TNF-α水平非常低，且与烧伤程度或预后无关。相比之下，整个临床过程中的血浆TNF-α最高水平与烧伤面积和预后显著相关。血浆TNF-α与血浆内毒素水平之间未发现相关性。TNF-α可能在感染性烧伤部位局部产生，监测血浆TNF-α水平可能是烧伤患者有用的预后指标。