苯二氮䓬类药物及其溶剂会影响中性粒细胞的功能。

Benzodiazepines and their solvents influence neutrophil granulocyte function.

作者信息

Weiss M, Mirow N, Birkhahn A, Schneider M, Wernet P

机构信息

Department of Anaesthesia, Heinrich-Heine-University, Düsseldorf, Germany.

出版信息

Br J Anaesth. 1993 Mar;70(3):317-21. doi: 10.1093/bja/70.3.317.

DOI:10.1093/bja/70.3.317

PMID:8471377

Abstract

We have examined the effects of commercially available preparations and drug-free solvents of diazepam (Valium, Diazepam-Lipuro) and midazolam (Dormicum) by N-formylmethionyl-leucylphenylalanine (FMLP)- and zymosan-induced polymorphonuclear cell (PMN) chemiluminescence and in a cell-free chemiluminescence system. In the case of Valium, drug-free solvent and diazepam suppressed PMN chemiluminescence. With Diazepam-Lipuro, the solvent stimulated and diazepam inhibited PMN chemiluminescence. With midazolam (Dormicum), only the active drug depressed PMN chemiluminescence. FMLP-induced PMN chemiluminescence was depressed 10-100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence.

摘要

我们通过N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）和酵母聚糖诱导的多形核细胞（PMN）化学发光以及无细胞化学发光系统，研究了市售地西泮制剂（安定、利眠宁）和无药物溶剂以及咪达唑仑（多美康）的作用。对于安定，无药物溶剂和地西泮均抑制PMN化学发光。对于利眠宁，溶剂刺激而地西泮抑制PMN化学发光。对于咪达唑仑（多美康），只有活性药物抑制PMN化学发光。地西泮和咪达唑仑对FMLP诱导的PMN化学发光的抑制作用比对酵母聚糖诱导的化学发光的抑制作用强10至100倍。