Buruk F, Berberoglu U, Pak I, Aksaz E, Celen O
Department of Pathology, Oncology Hospital, Ankara, Turkey.
Br J Surg. 1993 Mar;80(3):378-9. doi: 10.1002/bjs.1800800339.
Gastric adenocarcinoma can be divided into two histopathological types: intestinal and diffuse. In addition to the role of environmental factors, an association between gastric cancer and Helicobacter pylori has been suggested. A retrospective study was therefore carried out among 46 patients who had gastric cancer. As a control group, 40 patients with non-malignant disorders were selected (11 patients with peptic ulcer, 12 with chronic superficial gastritis, 17 with chronic atrophic gastritis). Twenty-six cancers were classified as intestinal type and 20 as diffuse type. H. pylori was found in 23 (88 per cent) of the intestinal type and 11 (55 per cent) of the diffuse type (P < 0.05). Patients with the intestinal-type gastric cancer had a higher prevalence of H. pylori infection than those with gastric ulcer (55 per cent) and chronic superficial gastritis (50 per cent) (P < 0.05). These findings suggest that there is a possible association between the intestinal type of gastric cancer and H. pylori infection.
肠型和弥漫型。除环境因素的作用外，胃癌与幽门螺杆菌之间也被认为存在关联。因此，对46例胃癌患者进行了一项回顾性研究。作为对照组，选取了40例患有非恶性疾病的患者（11例消化性溃疡患者、12例慢性浅表性胃炎患者、17例慢性萎缩性胃炎患者）。26例癌症被归类为肠型，20例为弥漫型。肠型胃癌中23例（88%）检测到幽门螺杆菌，弥漫型胃癌中11例（55%）检测到幽门螺杆菌（P<0.05）。肠型胃癌患者幽门螺杆菌感染率高于胃溃疡患者（55%）和慢性浅表性胃炎患者（50%）（P<0.05）。这些发现表明，肠型胃癌与幽门螺杆菌感染之间可能存在关联。
