Karim S M, Ratnam S S, Prasad R N, Wong Y M
Br J Obstet Gynaecol. 1977 Apr;84(4):269-71. doi: 10.1111/j.1471-0528.1977.tb12575.x.
A single pessary containing 0-5 mg 16, 16 dimethyl prostaglandin E2 p-benzaldehyde semicarbazone ester was used for cervical dilatation prior to vacuum aspiration in 124 first trimester nulliparae. Five hours after prostaglandin administration the cervix had dilated to 8 mm or more in 87 patients (70 per cent). The uterus was evacuated in these patients without mechanical dilatation of the cervix. In the remaining 37 patients the cervix had become soft and dilated 5 to 7 mm and further mechanical dilatation could be carried out easily. Side effects were minor and included vomiting in two patients, diarrhoea in one and transient pyrexia in two patients. There were no complications and no damage to the cervix or uterus during evacuation.
124例妊娠早期未产妇在真空吸引术前使用了一枚含0.5毫克16,16 - 二甲基前列腺素E2对苯甲醛缩氨基脲酯的子宫托进行宫颈扩张。给予前列腺素5小时后，87例患者（70%）的宫颈扩张至8毫米或更宽。这些患者在未进行宫颈机械扩张的情况下完成了子宫排空。其余37例患者的宫颈变软，扩张了5至7毫米，进一步的机械扩张可以轻松进行。副作用较小，包括2例患者呕吐、1例腹泻和2例患者短暂发热。在子宫排空过程中没有并发症，也没有对宫颈或子宫造成损伤。
