Queiroz M L, Costa F F, Bincoletto C, Perlingeiro R C, Dantas D C, Cardoso M P, Almeida M
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Brazil.
Int J Immunopharmacol. 1994 Mar;16(3):239-44. doi: 10.1016/0192-0561(94)90018-3.
Phagocytosis and intracellular killing of Candida albicans and Candida pseudotropicalis by neutrophils as well as phagocytic splenic function from lead-exposed workers were studied. Two species of Candida were used since in individuals with myeloperoxidase deficiency neutrophils are unable to kill C. albicans, whereas C. pseudotropicalis can be effectively lysed. Phagocytosis with both antigens and phagocytic splenic function were normal in all the workers studied. However, lytic activity towards C. albicans, but not C. pseudotropicalis was impaired. This defect was observed in lead-exposed workers with blood lead levels and urinary delta-aminolevulinic acid (ALA-U) concentrations in the "safe" (below 60 micrograms/dl and 6 mg/l, respectively) and toxic ranges. An impaired ability to kill C. albicans suggests that lead exposure may lead to a myeloperoxidase deficiency. With the exception of blood lead levels and ALA-U concentrations, there was no correlation between any of the other parameters examined.
研究了铅暴露工人中性粒细胞对白色念珠菌和伪热带念珠菌的吞噬作用及细胞内杀伤作用，以及脾脏的吞噬功能。使用了两种念珠菌，因为在髓过氧化物酶缺乏的个体中，中性粒细胞无法杀死白色念珠菌，而伪热带念珠菌可以被有效裂解。在所有研究的工人中，两种抗原的吞噬作用和脾脏的吞噬功能均正常。然而，对白色念珠菌的裂解活性受损，但对伪热带念珠菌的裂解活性未受损。在血铅水平和尿δ-氨基乙酰丙酸（ALA-U）浓度处于“安全”范围（分别低于60微克/分升和6毫克/升）及中毒范围内的铅暴露工人中均观察到了这种缺陷。杀灭白色念珠菌的能力受损表明铅暴露可能导致髓过氧化物酶缺乏。除血铅水平和ALA-U浓度外，所检测的任何其他参数之间均无相关性。
