Morrissette D L, Skinner M H, Hoffman B B, Levine R E, Davidson J M
Department of Molecular and Cellular Physiology, Stanford University, California 94305-5426.
Arch Sex Behav. 1993 Apr;22(2):99-109. doi: 10.1007/BF01542360.
Investigated the adverse sexual effects of two antihypertensive drugs, atenolol and slow-release nifedipine, in a placebo-controlled, randomized, crossover study. Subjects were 16 older men (mean age = 66.6 years, SEM = 1.4) with mild to moderate hypertension. Subjects completed daily self-reports on 13 measures of sexuality: frequency of desire, coitus, noncoital partner sex, masturbation, morning erections, spontaneous erections, orgasms in coitus and masturbation, firmness of morning, masturbatory and coital erections, and subjective pleasure in coitus and masturbation. Except for a significant decrease in masturbatory erectile firmness with nifedipine therapy, variables did not differ between the two drug treatments or between either drug and placebo. Although the sample was relatively small, small differences between treatment means suggest that these antihypertensive agents are fairly benign relative to sexual function in men.
在一项安慰剂对照、随机、交叉研究中，对两种抗高血压药物阿替洛尔和缓释硝苯地平的不良性功能影响进行了调查。受试者为16名老年男性（平均年龄 = 66.6岁，标准误 = 1.4），患有轻度至中度高血压。受试者每天就13项性指标完成自我报告：性欲频率、性交、与性伴侣的非性交性行为、手淫、晨勃、自发勃起、性交和手淫时的性高潮、晨勃、手淫勃起和性交勃起的硬度，以及性交和手淫时的主观愉悦感。除硝苯地平治疗使手淫勃起硬度显著降低外，两种药物治疗之间以及任一药物与安慰剂之间的变量没有差异。尽管样本相对较小，但治疗均值之间的微小差异表明，相对于男性性功能而言，这些抗高血压药物相当温和。
