Payan H M, Conrad J R
Stroke. 1977 Mar-Apr;8(2):194-6. doi: 10.1161/01.str.8.2.194.
The ill effects of carotid artery occlusion or ligation vary in man and experimental animals according to surgical techniques, environmental conditions, diet, stress, sex, age, strain of the animal, blood pressure, the state of cardiopulmonary system, and other diverse factors. Unilateral carotid artery ligation in most small laboratory animals is an innocuous procedure. The gerbil, a desert rat, has been found to be quite sensitive to unilateral carotid artery ligation. The present experiments were designed to study the influence of age, sex, and castration on end results of the unilateral carotid artery ligation in gerbils. It appears that the young animals prior to sexual maturity and the sexually mature female are more resistant than the sexually mature male. This difference is assumed to be due to the influence of the gonads on the blood flow of the brain.
颈动脉闭塞或结扎的不良影响在人类和实验动物中因手术技术、环境条件、饮食、压力、性别、年龄、动物品系、血压、心肺系统状态以及其他多种因素而有所不同。在大多数小型实验动物中，单侧颈动脉结扎是一种无害的操作。人们发现沙鼠，一种沙漠鼠，对单侧颈动脉结扎相当敏感。本实验旨在研究年龄、性别和去势对沙鼠单侧颈动脉结扎最终结果的影响。似乎性成熟前的幼龄动物和性成熟的雌性动物比性成熟的雄性动物更具抵抗力。这种差异被认为是由于性腺对脑血流的影响。
