新型抗生素氰环素A。产生菌的分类学、发酵、分离与特性研究。

Cyanocycline A, a new antibiotic. Taxonomy of the producing organism, fermentation, isolation and characterization.

作者信息

Hayashi T, Noto T, Nawata Y, Okazaki H, Sawada M, Ando K

出版信息

J Antibiot (Tokyo). 1982 Jul;35(7):771-7. doi: 10.7164/antibiotics.35.771.

DOI:10.7164/antibiotics.35.771

Abstract

A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.

摘要

一种新的抗生素——氰基环素A，是从土壤分离物黄灰链霉菌49号菌株的发酵液中分离得到的。氰基环素A的分子式确定为C22H26N4O5。该抗生素结构中含有一个氰基和一个N-杂环醌部分。发现氰基环素A具有广谱抗菌和抗肿瘤活性。