从墨西哥花椒属植物中合成喹唑啉-2,4-二酮生物碱及其类似物。
Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species.
作者信息
Rivero I A, Espinoza K, Somanathan R
机构信息
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166. 22000, Tijuana, BC México.
出版信息
Molecules. 2004 Jun 30;9(7):609-16. doi: 10.3390/90700609.
Abstract
Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones. The previous isolation of two of these compounds, namely 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2'-(4'- methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione, from the seed husks of Mexican Zanthoxylum species has been reported.
摘要
喹唑啉酮和喹唑啉二酮衍生物因其广泛的药理特性而备受关注。在本文中，我们报道了十种喹唑啉二酮的合成。此前已报道从墨西哥花椒属植物的种皮中分离出其中两种化合物，即1-甲基-3-(2'-苯乙基)-1H,3H-喹唑啉-2,4-二酮和1-甲基-3-[2'-(4'-甲氧基苯基)乙基]-1H,3H-喹唑啉-2,4-二酮。
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