相似文献

1

Le interferon mRNA from human fibroblasts.来自人成纤维细胞的γ干扰素信使核糖核酸。

Proc Natl Acad Sci U S A. 1980 Sep;77(9):5341-5. doi: 10.1073/pnas.77.9.5341.

2

Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production.人成纤维细胞在干扰素产生的诱导、关闭和超诱导过程中的干扰素信使核糖核酸含量。

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3409-13. doi: 10.1073/pnas.74.8.3409.

3

Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells.非洲爪蟾卵母细胞合成人干扰素：人类细胞中干扰素的两个结构基因。

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3287-91. doi: 10.1073/pnas.74.8.3287.

4

Isolation and cell-free translation of human interferon mRNA from fibroblasts and leukocytes.从成纤维细胞和白细胞中分离人干扰素信使核糖核酸并进行无细胞翻译

Methods Enzymol. 1981;79(Pt B):51-9. doi: 10.1016/s0076-6879(81)79012-8.

5

Heterogeneity of poly(I) x poly(C)-induced human fibroblast interferon mRNA species.聚肌苷酸×聚胞苷酸诱导的人成纤维细胞干扰素mRNA种类的异质性。

Nature. 1980 Nov 6;288(5786):95-7. doi: 10.1038/288095a0.

6

Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.对诱导产生干扰素的人成纤维细胞中干扰素信使核糖核酸的分析。

Proc Natl Acad Sci U S A. 1981 Dec;78(12):7426-30. doi: 10.1073/pnas.78.12.7426.

7

Induction and decay of human fibroblast interferon mRNA.人成纤维细胞干扰素mRNA的诱导与衰减

Proc Natl Acad Sci U S A. 1977 Oct;74(10):4415-9. doi: 10.1073/pnas.74.10.4415.

8

[Determination of the species specificity of interferons in the translation of the their mRNA from various cell cultures].[在从各种细胞培养物翻译干扰素信使核糖核酸过程中干扰素物种特异性的测定]

Antibiotiki. 1983 Jan;28(1):27-31.

9

Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in oocytes of Xenopus laevis?3'末端的聚腺苷酸（poly(A)）是否能稳定非洲爪蟾卵母细胞中的人成纤维细胞干扰素mRNA？

Proc Natl Acad Sci U S A. 1978 Oct;75(10):5030-3. doi: 10.1073/pnas.75.10.5030.

10

Translational activity and functional stability of human fibroblast beta 1 and beta 2 interferon mRNAs lacking 3'-terminal RNA sequences.缺乏3'-末端RNA序列的人成纤维细胞β1和β2干扰素mRNA的翻译活性和功能稳定性。

Proc Natl Acad Sci U S A. 1981 Mar;78(3):1741-5. doi: 10.1073/pnas.78.3.1741.

引用本文的文献

1

Structure of a chromosomal gene for human interferon beta.人干扰素β基因的结构。

Proc Natl Acad Sci U S A. 1981 Sep;78(9):5305-9. doi: 10.1073/pnas.78.9.5305.

2

Human fibroblast interferon RNA transcripts of different sizes in poly(I).poly(C) induced cells.聚肌苷酸-聚胞苷酸（poly(I).poly(C)）诱导细胞中不同大小的人成纤维细胞干扰素RNA转录本

Nucleic Acids Res. 1983 May 11;11(9):2627-38. doi: 10.1093/nar/11.9.2627.

3

Inhibition of interferon production in human fibroblasts by a tumor promoting phorbol ester.一种促肿瘤佛波酯对人成纤维细胞中干扰素产生的抑制作用。

Arch Virol. 1982;73(3-4):295-309. doi: 10.1007/BF01318083.

4

Partial characterization of gamma (immune) interferon mRNA extracted from human lymphocytes.从人淋巴细胞中提取的γ（免疫）干扰素信使核糖核酸的部分特性分析

Proc Natl Acad Sci U S A. 1981 Jun;78(6):3469-72. doi: 10.1073/pnas.78.6.3469.

本文引用的文献

1

Characterization of interferon messenger RNA synthesis in Namalva cells.纳马鲁瓦细胞中干扰素信使核糖核酸合成的特性研究

J Biol Chem. 1980 Apr 10;255(7):2955-61.

2

Amino terminal sequence of the major component of human lymphoblastoid interferon.人淋巴母细胞样干扰素主要成分的氨基末端序列。

Science. 1980 Feb 1;207(4430):527-8. doi: 10.1126/science.7352260.

3

Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.人成纤维细胞干扰素：氨基酸分析及氨基末端氨基酸序列

Science. 1980 Feb 1;207(4430):525-6. doi: 10.1126/science.7352259.

4

The nucleotide sequence of human fibroblast interferon cDNA.人成纤维细胞干扰素cDNA的核苷酸序列。

Gene. 1980 Jun;10(1):11-5. doi: 10.1016/0378-1119(80)90138-9.

5

The nucleotide sequence of a cloned human leukocyte interferon cDNA.克隆的人白细胞干扰素cDNA的核苷酸序列。

Gene. 1980 Jun;10(1):1-10. doi: 10.1016/0378-1119(80)90137-7.

6

Human leukocyte and fibroblast interferons are structurally related.人白细胞干扰素和成纤维细胞干扰素在结构上相关。

Nature. 1980 Jun 19;285(5766):547-9. doi: 10.1038/285547a0.

7

Interferon messenger RNA: translation in heterologous cells.干扰素信使核糖核酸：在异源细胞中的翻译

Proc Natl Acad Sci U S A. 1972 May;69(5):1203-7. doi: 10.1073/pnas.69.5.1203.

8

Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature.通过用代谢抑制剂处理细胞并降低孵育温度来稳定干扰素信使核糖核酸的活性。

Proc Natl Acad Sci U S A. 1973 Dec;70(12):3909-13. doi: 10.1073/pnas.70.12.3909.

9

The somatic cell genetics of human interferon: assignment of human interferon loci to chromosomes 2 and 5.人类干扰素的体细胞遗传学：将人类干扰素基因座定位于2号和5号染色体

Proc Natl Acad Sci U S A. 1974 Jun;71(6):2251-5. doi: 10.1073/pnas.71.6.2251.

10

Affinity chromatography of human leukocyte and diploid cell interferons on sepharose-bound antibodies.人白细胞干扰素和二倍体细胞干扰素在琼脂糖结合抗体上的亲和层析

J Immunol. 1975 Feb;114(2 Pt 1):640-4.

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来自人成纤维细胞的γ干扰素信使核糖核酸。

Le interferon mRNA from human fibroblasts.

作者信息

Pang R H, Hayes T G, Vilcek J

出版信息

Proc Natl Acad Sci U S A. 1980 Sep;77(9):5341-5. doi: 10.1073/pnas.77.9.5341.

DOI:10.1073/pnas.77.9.5341

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350054/

Abstract

Human F and Le interferon can be clearly distinguished on the basis of different antigenic properties and host range. After inoculation with Newcastle disease virus (NDV), GM-258 fibroblasts produced Le as well as F interferon; in contrast, only F interferon was detectable after stimulation with poly(I) . poly(C). Polyadenylylated mRNA isolated from fibroblasts induced with poly(I) . poly(C) or NDV was injected into Xenopus laevis oocytes and the interferon activities thus produced were analyzed. Only F interferon production was demonstrable in oocytes injected with mRNA from cells induced with poly(I) . poly(C), whereas both F and Le interferons were made in oocytes injected with mRNA from NDV-induced cultures. The time course of accumulation of F and Le interferon mRNAs in NDV-induced cells corresponded to the kinetics of F and Le interferon synthesis in intact cells. The ratio of F and Le interferons made in oocytes was similar to that observed in intact GM-258 cells. F and Le interferon mRNA activities isolated from GM-258 cells could not be separated by sucrose density gradient centrifugation. However, the profile of F mRNA activity was more heterogeneous and its peak sedimented somewhat more slowly than that of Le interferon mRNA. These results suggest that the varying ratios of F and Le interferon synthesis in different cells after different modes of stimulation are determined at the level of mRNA. The induction mechanisms of F and Le interferon mRNA synthesis appear to be closely related but not identical.

摘要

人F干扰素和Le干扰素可根据不同的抗原特性和宿主范围明确区分。用新城疫病毒（NDV）接种后，GM - 258成纤维细胞产生Le干扰素和F干扰素；相反，用聚肌苷酸-聚胞苷酸（poly(I)·poly(C)）刺激后仅可检测到F干扰素。将从用poly(I)·poly(C)或NDV诱导的成纤维细胞中分离出的多聚腺苷酸化mRNA注射到非洲爪蟾卵母细胞中，并分析由此产生的干扰素活性。在用poly(I)·poly(C)诱导的细胞的mRNA注射的卵母细胞中仅可证明有F干扰素产生，而在用NDV诱导培养物的mRNA注射的卵母细胞中F干扰素和Le干扰素均有产生。在NDV诱导的细胞中F干扰素和Le干扰素mRNA积累的时间进程与完整细胞中F干扰素和Le干扰素合成的动力学一致。在卵母细胞中产生的F干扰素和Le干扰素的比例与在完整的GM - 258细胞中观察到的相似。从GM - 258细胞中分离出的F干扰素和Le干扰素mRNA活性不能通过蔗糖密度梯度离心分离。然而，F mRNA活性的分布更不均一，其峰值沉降速度比Le干扰素mRNA略慢。这些结果表明，在不同刺激模式后不同细胞中F干扰素和Le干扰素合成比例的变化是在mRNA水平上决定的。F干扰素和Le干扰素mRNA合成的诱导机制似乎密切相关但并不相同。