Bartelink M L, Wollersheim H, Jansen R W, Theeuwes A, Thien T
Department of Medicine, University Hospital Nijmegen, The Netherlands.
Microvasc Res. 1993 Jan;45(1):65-73. doi: 10.1006/mvre.1993.1006.
A finger cooling test is used to objectify Raynaud's phenomenon and to assess its severity. For this purpose, finger skin temperature (FST) and laser Doppler flux (LDF) are measured on the fingertips before and during cooling of the hand (16 degrees water bath for 5 min) and a subsequent recovery period (20 min). To study reproducibility, this test was performed twice within 3 months in 34 healthy subjects and in 56 Raynaud patients. Three test parameters were used in the analysis: the baseline value, the value after 12 min of recovery, and the mean level during recovery. We determined the limits of agreement (mean differences between the first and the second test +/- 2SD) and the coefficients of variation. No systematic differences between the first and the second test were found. Outside temperature did not influence FST or LDF. FST was shown to have a better reproducibility than LDF. For the baseline value in the total group the coefficient of variation was 3.3% for FST and, rather high, 21.6% for LDF. The limits of agreement for the baseline value in the total group were -4.8 to 4.2 degrees for FST and -25.2 to 22.2 arbitrary units for LDF. In conclusion, the applied cooling test has limited value in individual cases, but can be useful when comparing large groups in pathophysiologic or therapeutic studies.
手指冷却试验用于客观评估雷诺现象及其严重程度。为此，在手冷却（置于16摄氏度水浴中5分钟）及随后的恢复阶段（20分钟）前后，测量指尖的手指皮肤温度（FST）和激光多普勒血流（LDF）。为研究可重复性，对34名健康受试者和56名雷诺病患者在3个月内进行了两次该试验。分析中使用了三个测试参数：基线值、恢复12分钟后的数值以及恢复期间的平均水平。我们确定了一致性界限（第一次和第二次测试之间的平均差异±2SD）和变异系数。未发现第一次和第二次测试之间存在系统差异。外界温度未影响FST或LDF。结果表明，FST的可重复性优于LDF。在整个组中，FST基线值的变异系数为3.3%，而LDF的变异系数较高，为21.6%。整个组基线值的一致性界限，FST为-4.8至4.2摄氏度，LDF为-25.2至22.2任意单位。总之，所应用的冷却试验在个别病例中的价值有限，但在病理生理学或治疗研究中比较大组时可能有用。
