Sachs M, Encke A
Klinik für Allgemeinchirurgie, Johann Wolfgang Goethe-Universität Frankfurt am Main.
Zentralbl Chir. 1993;118(3):160-5.
The present reports on a 51-year-old patient who presented with weight loss, anaemia, hypoalbuminaemia and ankle oedema, and was referred for laparotomy by a radiologist on the grounds of suspected carcinoma of the stomach suggested by an upper gastrointestinal x-ray series. Surgery revealed excessively thickened rugae with gyrus-like, tortuous surface epithelium folds (histologically Ménétrier's disease). A gastrectomy was performed, and the patient has been symptom-free and active ever since. In addition, the author presents a review of the literature published to date describing case reports of patients with Ménétrier's disease. Ménétrier's disease is a benign condition of the gastric mucosa in which gastric loss of albumin has been shown to be responsible for hypoalbuminaemia. The diagnostic procedure of choice is gastroscopy because upper gastrointestinal x-ray series cannot distinguish between carcinoma of the stomach with certainty. Since this is a chronic disease that does not respond to medication, treatment of choice today is (partial) gastrectomy dictated by the extent and severity of the findings.
本报告讲述了一名51岁的患者，该患者出现体重减轻、贫血、低白蛋白血症和脚踝水肿，因上消化道X线系列检查怀疑为胃癌，由放射科医生转诊进行剖腹手术。手术发现胃皱襞过度增厚，表面上皮褶皱呈脑回状、扭曲（组织学上为门脉高压性胃病）。进行了胃切除术，此后患者一直无症状且活动自如。此外，作者还对迄今为止发表的描述门脉高压性胃病患者病例报告的文献进行了综述。门脉高压性胃病是一种胃黏膜的良性疾病，其中胃白蛋白丢失已被证明是低白蛋白血症的原因。首选的诊断方法是胃镜检查，因为上消化道X线系列检查不能确定地鉴别胃癌。由于这是一种对药物治疗无反应的慢性病，目前根据检查结果的范围和严重程度，首选的治疗方法是（部分）胃切除术。
