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庆大霉素的血凝抑制试验

Hemagglutination inhibition assay for gentamicin.

作者信息

Mahon W A, Feldman R I, Scherr G H

出版信息

Antimicrob Agents Chemother. 1977 Feb;11(2):359-61. doi: 10.1128/AAC.11.2.359.

DOI:10.1128/AAC.11.2.359
PMID:848941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC351979/
Abstract

A rapid and simple hemagglutination inhibition test for measuring gentamicin concentrations in serum has been developed. Correlation coefficients for this assay with the radioimmunoassay and microbiological assay were r = 710 and r = 0.864, respectively. Measurements of gentamicin levels in serum by the three methods showed no statistically significant differences. The hemagglutination inhibition assay is fast, reliable, and relatively inexpensive, and should prove valuable for laboratory use.

摘要

已开发出一种用于测定血清中庆大霉素浓度的快速简便的血凝抑制试验。该测定法与放射免疫测定法和微生物测定法的相关系数分别为r = 0.710和r = 0.864。用这三种方法测定血清中的庆大霉素水平,结果显示无统计学显著差异。血凝抑制试验快速、可靠且相对便宜,应该会被证明对实验室使用很有价值。

相似文献

1
Hemagglutination inhibition assay for gentamicin.庆大霉素的血凝抑制试验
Antimicrob Agents Chemother. 1977 Feb;11(2):359-61. doi: 10.1128/AAC.11.2.359.
2
Latex agglutination inhibition card test for gentamicin assay: clinical evaluation and comparison with radioimmunoassay and bioassay.用于庆大霉素测定的乳胶凝集抑制卡片试验:临床评估以及与放射免疫测定法和生物测定法的比较
Antimicrob Agents Chemother. 1981 Apr;19(4):620-4. doi: 10.1128/AAC.19.4.620.
3
Serum gentamicin assay by a radiometric procedure.
Am J Clin Pathol. 1980 Feb;73(2):259-62. doi: 10.1093/ajcp/73.2.259.
4
Evaluation of a new latex agglutination inhibition card test for determining serum gentamicin levels.一种用于测定血清庆大霉素水平的新型乳胶凝集抑制卡片试验的评估。
Antimicrob Agents Chemother. 1981 May;19(5):930-3. doi: 10.1128/AAC.19.5.930.
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Comparison of latex agglutination inhibition test & bioassays for rapid estimation of serum gentamicin levels.乳胶凝集抑制试验与生物测定法用于快速估算血清庆大霉素水平的比较。
Indian J Med Res. 1986 Dec;84:645-9.
6
Radioimmunoassay, acetylating radio-enzymatic assay, and microbioassay of gentamicin: a comparative study.庆大霉素的放射免疫测定、乙酰化放射酶法测定及微生物测定:一项比较研究。
J Lab Clin Med. 1975 Aug;86(2):349-59.
7
An evaluation of a gentamicin fluoroimmunoassay kit; correlation with radioimmunoassay, acetyl transferase and microbiological assay.
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An improved radioimmunoassay for serum gentamicin levels using 125I-labelled gentamicin.一种使用¹²⁵I标记庆大霉素的血清庆大霉素水平改良放射免疫测定法。
Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):525-32. doi: 10.1111/j.1440-1681.1977.tb02682.x.
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Radioimmunoassay as an improved method for measurement of serum levels of gentamicin.放射免疫测定法作为一种测定血清庆大霉素水平的改进方法。
Med J Aust. 1976 May 15;1(20):738-40. doi: 10.5694/j.1326-5377.1976.tb141020.x.
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Radioimmunoassay of iodinated gentamicin.碘化庆大霉素的放射免疫测定法
Clin Chim Acta. 1976 Jan 2;66(1):125-9. doi: 10.1016/0009-8981(76)90379-x.

引用本文的文献

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Performance characteristics of bioassay, radioenzymatic assay, homogeneous enzyme immunoassay, and high-performance liquid chromatographic determination of serum gentamicin.生物测定、放射酶测定、均相酶免疫测定以及血清庆大霉素的高效液相色谱测定的性能特征
Antimicrob Agents Chemother. 1982 Jan;21(1):19-25. doi: 10.1128/AAC.21.1.19.
2
Serum aminoglycoside assay by enzyme-mediated immunoassay (EMIT): correlation with radioimmunoassay, microbiological assays.酶介导免疫分析法(EMIT)检测血清氨基糖苷类药物:与放射免疫分析法、微生物学检测法的相关性
Antimicrob Agents Chemother. 1981 Jun;19(6):1064-6. doi: 10.1128/AAC.19.6.1064.
3
Therapeutic drug monitoring of aminoglycoside antibiotics.氨基糖苷类抗生素的治疗药物监测
Infection. 1980;8 Suppl 3:S 313-20. doi: 10.1007/BF01639603.

本文引用的文献

1
Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.庆大霉素对人体的耳毒性:美国临床经验的调查与对照分析
J Infect Dis. 1971 Dec;124 Suppl:S130-7. doi: 10.1093/infdis/124.supplement_1.s130.
2
Detection of morphine by hemagglutination-inhibition.通过血凝抑制法检测吗啡。
J Immunol. 1971 Jan;106(6):1684-5.
3
Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin.假单胞菌属菌血症:庆大霉素治疗失败的药理学及其他原因
J Infect Dis. 1971 Dec;124 Suppl:S185-91. doi: 10.1093/infdis/124.supplement_1.s185.
4
Radioimmunoassay for measurement of gentamicin in blood.用于测量血液中庆大霉素的放射免疫测定法。
Antimicrob Agents Chemother. 1973 May;3(5):585-9. doi: 10.1128/AAC.3.5.585.
5
Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis.严重革兰氏阴性菌败血症治疗期间监测庆大霉素治疗的经验。
Br Med J. 1974 Mar 16;1(5906):477-81. doi: 10.1136/bmj.1.5906.477.
6
Immunologic studies on drug addiction. I. Antibodies reactive with methadone and their use for detection of the drug.药物成瘾的免疫学研究。I. 与美沙酮反应的抗体及其在药物检测中的应用。
J Immunol. 1973 Aug;111(2):472-7.
7
Radioimmunoassay, acetylating radio-enzymatic assay, and microbioassay of gentamicin: a comparative study.庆大霉素的放射免疫测定、乙酰化放射酶法测定及微生物测定:一项比较研究。
J Lab Clin Med. 1975 Aug;86(2):349-59.