Seki T, Morohashi M
Department of Dermatology, Toyama Medical and Pharmaceutical University, Japan.
Skin Pharmacol. 1993;6(1):56-60. doi: 10.1159/000211087.
The effects of some alkaloids and flavonoids, which are major ingredients in some of the Japanese Kampoh drugs (Japanese-Chinese traditional herbal medicines) experientially known to be efficacious for the treatment of acne vulgaris, on the lipogenesis in the sebaceous glands of the hamster ear, an excellent animal model for the human sebaceous gland, were studied. Lipogenesis was assayed by determining 14C incorporation into sebaceous lipids extracted from the sebaceous glands which were preincubated with 14C-acetate. We found that the lipogenesis in the hamster sebaceous glands was suppressed 63 and 54% by 10(-4) M berberine (an alkaloid) and wogonin (a flavonoid), respectively. We suggest that the therapeutic effects of some Japanese Kampoh drugs experimentally used for acne vulgaris could be due to inhibition of lipogenesis by their active ingredients such as berberine and wogonin.
某些日本汉方药物（日中传统草药）的主要成分生物碱和黄酮类化合物，根据经验已知对寻常痤疮的治疗有效，本研究观察了它们对金黄地鼠耳部皮脂腺脂质生成的影响，金黄地鼠耳部是一种很好的人类皮脂腺动物模型。脂质生成通过测定14C掺入预先用14C-醋酸盐孵育的皮脂腺提取的皮脂脂质中来进行检测。我们发现，10（-4）M黄连素（一种生物碱）和汉黄芩素（一种黄酮类化合物）分别使金黄地鼠皮脂腺中的脂质生成抑制了63%和54%。我们认为，一些实验性用于寻常痤疮的日本汉方药物的治疗作用可能归因于其活性成分如黄连素和汉黄芩素对脂质生成的抑制作用。
