Clark Ashley K, Haas Kelly N, Sivamani Raja K
School of Medicine, University of California-Davis, Sacramento, CA 95816, USA.
Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA.
Int J Mol Sci. 2017 May 17;18(5):1070. doi: 10.3390/ijms18051070.
Acne vulgaris affects most people at some point in their lives. Due to unclear etiology, likely with multiple factors, targeted and low-risk treatments have yet to be developed. In this review, we explore the multiple causes of acne and how plant-based foods and supplements can control these. The proposed causative factors include insulin resistance, sex hormone imbalances, inflammation and microbial dysbiosis. There is an emerging body of work on the human gut microbiome and how it mediates feedback between the foods we eat and our bodies. The gut microbiome is also an important mediator of inflammation in the gut and systemically. A low-glycemic load diet, one rich in plant fibers and low in processed foods, has been linked to an improvement in acne, possibly through gut changes or attenuation of insulin levels. Though there is much interest in the human microbiome, there is much more unknown, especially along the gut-skin axis. Collectively, the evidence suggests that approaches such as plant-based foods and supplements may be a viable alternative to the current first line standard of care for moderate acne, which typically includes antibiotics. Though patient compliance with major dietary changes is likely much lower than with medications, it is a treatment avenue that warrants further study and development.
寻常痤疮在大多数人的生命中的某个阶段都会出现。由于病因不明，可能涉及多种因素，目前尚未开发出有针对性的低风险治疗方法。在这篇综述中，我们探讨了痤疮的多种成因以及植物性食物和补充剂如何控制这些成因。提出的致病因素包括胰岛素抵抗、性激素失衡、炎症和微生物群落失调。关于人类肠道微生物群及其如何介导我们所吃食物与身体之间的反馈，有越来越多的研究成果。肠道微生物群也是肠道和全身炎症的重要调节因子。低升糖负荷饮食，即富含植物纤维且加工食品含量低的饮食，与痤疮改善有关，可能是通过肠道变化或胰岛素水平的降低实现的。尽管人们对人类微生物群很感兴趣，但仍有很多未知之处，尤其是在肠道与皮肤的轴线上。总体而言，证据表明，植物性食物和补充剂等方法可能是中度痤疮当前一线标准治疗方法（通常包括抗生素）的可行替代方案。尽管患者对重大饮食改变的依从性可能远低于药物治疗，但这是一个值得进一步研究和开发的治疗途径。
