Klingen G, Johansson L, Westerholm C J, Sundstroöm C
Ann Thorac Surg. 1977 Apr;23(4):342-7. doi: 10.1016/s0003-4975(10)64138-0.
Fifty-eight patients with myasthenia gravis, including 12 children, underwent thymectomy. Eleven of them (19%) had total stable remission and 42 (72%) showed clinical improvement and were able to reduce their anticholinesterase medication. These two groups combined comprised 53 patients (91%). There was no operative or postoperative mortality. Histopathological examination of the resected thymuses revealed a tumor (benign thymoma) in 4 patients (7%), thymitis in 36(62%), and no pathological changes in 18(31%). Patients with few or no germinal centers tended to achieve remission more rapidly than those with numerous germinal centers.
58例重症肌无力患者接受了胸腺切除术，其中包括12名儿童。他们中有11例（19%）完全稳定缓解，42例（72%）临床症状改善，能够减少抗胆碱酯酶药物用量。这两组患者共有53例（91%）。无手术及术后死亡病例。切除胸腺的组织病理学检查显示，4例（7%）有肿瘤（良性胸腺瘤），36例（62%）有胸腺炎，18例（31%）无病理改变。生发中心少或无生发中心的患者比生发中心多的患者更容易迅速达到缓解。
