Sofia R D, Knobloch L C, Harakal J J, Erikson D J
Arch Int Pharmacodyn Ther. 1977 Jan;225(1):77-87.
Orally administered delta9-tetrahydrocannabinol (THC) produced a dose-dependent increase in urine output in hydrated rats similar in mg/kg potency and magnitude of effect to hydrochlorothiazide (HCT). Whereas HCT promoted marked excretion of Na+, K+ and Cl- and an increase in the urinary Na+/K+ at all diuretic doses (1.25-20.0 mg/kg), THC had only a slight effect on Na+ and K+ excretion but not Cl- even after the highest dose tested (20.0 mg/kg). Hypophysectomy and adrenalectomy abolished the diuretic effect of THC, thus suggesting both central and peripheral sites of action for the diuretic effect of THC. Tolerance to the effect on urine output by THC developed after 15 days of repeated dosing, while urine output and electrolyte excretion remained significantly elevated after 25 days of HCT administration.
经口给予δ9-四氢大麻酚（THC）可使水合大鼠的尿量呈剂量依赖性增加，其每千克体重的效力和作用幅度与氢氯噻嗪（HCT）相似。尽管在所有利尿剂量（1.25 - 20.0 mg/kg）下，HCT都会促使Na+、K+和Cl-大量排泄，并使尿Na+/K+升高，但即使在测试的最高剂量（20.0 mg/kg）下，THC对Na+和K+排泄的影响也很小，对Cl-则无影响。垂体切除和肾上腺切除消除了THC的利尿作用，这表明THC的利尿作用既有中枢作用位点，也有外周作用位点。重复给药15天后，机体对THC对尿量的影响产生了耐受性，而在给予HCT 25天后，尿量和电解质排泄仍显著升高。
