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1
The release of alanine by rat diaphragm muscle in vitro.大鼠膈肌在体外释放丙氨酸的情况。
Biochem J. 1977 Feb 15;162(2):399-403. doi: 10.1042/bj1620399.
2
The role of phosphoenolpyruvate carboxykinase in muscle alanine synthesis.磷酸烯醇式丙酮酸羧激酶在肌肉丙氨酸合成中的作用。
Biochem J. 1984 Dec 15;224(3):971-6. doi: 10.1042/bj2240971.
3
Pyruvate kinase and alanine synthesis in skeletal muscle.骨骼肌中的丙酮酸激酶与丙氨酸合成
Biosci Rep. 1982 Nov;2(11):941-8. doi: 10.1007/BF01114901.
4
Alanine release by rat hemidiaphragm muscle in vitro.大鼠半膈肌在体外释放丙氨酸的情况。
Biochem Soc Trans. 1976;4(2):287-8. doi: 10.1042/bst0040287.
5
The formation of alanine from amino acids in diaphragm muscle of the rat.大鼠膈肌中氨基酸生成丙氨酸的过程。
Biochem J. 1976 Feb 15;154(2):555-8. doi: 10.1042/bj1540555.
6
Amino acid oxidation and alanine production in rat hemidiaphragm in vitro. Effects of dichloroacetate.大鼠半膈膜体外氨基酸氧化及丙氨酸生成。二氯乙酸的作用。
Biochem J. 1984 Oct 1;223(1):113-7. doi: 10.1042/bj2230113.
7
Alanine and inter-organ relationships in branched-chain amino and 2-oxo acid metabolism. Review.丙氨酸与支链氨基酸和2-氧代酸代谢中的器官间关系。综述。
Biosci Rep. 1985 Dec;5(12):1015-33. doi: 10.1007/BF01119623.
8
Alanine formation by rat muscle homogenate.
Biochem Biophys Res Commun. 1973 Jul 2;53(1):251-7. doi: 10.1016/0006-291x(73)91427-7.
9
Muscle phosphoenolpyruvate carboxykinase activity and alanine release in progressively starved rats.
Int J Biochem. 1979;10(5):423-6. doi: 10.1016/0020-711x(79)90066-1.
10
Sources of carbon skeleton of alanine released from skeletal muscle.从骨骼肌释放的丙氨酸碳骨架的来源。
Acta Physiol Scand. 1976 Jul;97(3):273-80. doi: 10.1111/j.1748-1716.1976.tb10264.x.

引用本文的文献

1
What is the metabolic role of phosphoenolpyruvate carboxykinase?磷酸烯醇式丙酮酸羧激酶的代谢作用是什么？
J Biol Chem. 2009 Oct 2;284(40):27025-9. doi: 10.1074/jbc.R109.040543. Epub 2009 Jul 27.
2
Born to run; the story of the PEPCK-Cmus mouse.为跑而生；磷酸烯醇式丙酮酸羧激酶-肌肉特异性小鼠的故事。
Biochimie. 2008 Jun;90(6):838-42. doi: 10.1016/j.biochi.2008.03.009. Epub 2008 Apr 3.
3
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.骨骼肌中磷酸烯醇式丙酮酸羧激酶（GTP）胞质形式的过表达改变了小鼠的能量代谢模式。
J Biol Chem. 2007 Nov 9;282(45):32844-55. doi: 10.1074/jbc.M706127200. Epub 2007 Aug 23.
4
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.磷酸烯醇式丙酮酸羧激酶与回补反应在肝脏代谢调控中的关键作用。
Nutr Metab (Lond). 2005 Nov 21;2:33. doi: 10.1186/1743-7075-2-33.
5
Branched-chain amino acid nitrogen transfer to alamine in vivo in dogs. Direct isotopic determination with [15N]leucine.犬体内支链氨基酸氮向丙氨酸的转移。用[15N]亮氨酸进行直接同位素测定。
J Clin Invest. 1980 Dec;66(6):1295-304. doi: 10.1172/JCI109981.
6
Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone-body and glutamine utilization pathways in lymphocytes of the rat.大鼠淋巴细胞中糖酵解、三羧酸循环以及酮体和谷氨酰胺利用途径的某些酶的最大活性
Biochem J. 1982 Dec 15;208(3):743-8. doi: 10.1042/bj2080743.
7
The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.胰岛素依赖型糖尿病患者对高血糖钳夹的代谢反应。
Diabetologia. 1981 Feb;20(2):113-7. doi: 10.1007/BF00262012.
8
Enzymic determination of branched-chain amino acids and 2-oxoacids in rat tissues. Transfer of 2-oxoacids from skeletal muscle to liver in vivo.大鼠组织中支链氨基酸和2-氧代酸的酶法测定。体内2-氧代酸从骨骼肌向肝脏的转运。
Biochem J. 1980 Jun 15;188(3):705-13. doi: 10.1042/bj1880705.
9
Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.大鼠膈肌体外支链氨基酸代谢及丙氨酸生成。二氯乙酸的作用。
Biochem J. 1984 Nov 1;223(3):831-5. doi: 10.1042/bj2230831.
10
Effects of parathyroid hormone on skeletal muscle protein and amino acid metabolism in the rat.甲状旁腺激素对大鼠骨骼肌蛋白质和氨基酸代谢的影响。
J Clin Invest. 1983 Jun;71(6):1806-21. doi: 10.1172/jci110936.

本文引用的文献

1
Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).二氯乙酸对灌流大鼠心脏丙酮酸脱氢酶的激活（简短通讯）。
Biochem J. 1973 Jun;134(2):651-3. doi: 10.1042/bj1340651.
2
Effect of free fatty acids and insulin on protein synthesis and amino acid metabolism of isolated rat diaphragms.游离脂肪酸和胰岛素对大鼠离体膈肌蛋白质合成及氨基酸代谢的影响。
Diabetes. 1967 Nov;16(11):753-64. doi: 10.2337/diab.16.11.753.
3
Hormone-fuel interrelationships during fasting.禁食期间激素与能量的相互关系。
J Clin Invest. 1966 Nov;45(11):1751-69. doi: 10.1172/JCI105481.
4
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels.空腹状态下人体前臂各组织间的氨基酸平衡。两种剂量胰岛素的作用。
J Clin Invest. 1969 Dec;48(12):2273-82. doi: 10.1172/JCI106193.
5
The pathway of gluconeogenesis in the cortex of guinea-pig kidney. Use of aminooxyacetate as a transaminase inhibitor.豚鼠肾皮质中糖异生的途径。使用氨基氧乙酸作为转氨酶抑制剂。
Eur J Biochem. 1972 Feb 15;25(2):366-71. doi: 10.1111/j.1432-1033.1972.tb01705.x.
6
Studies with isolated surviving rat hearts. Interdependence of free amino acids and citric-acid-cycle intermediates.对离体存活大鼠心脏的研究。游离氨基酸与柠檬酸循环中间产物的相互依存关系。
Eur J Biochem. 1973 Sep 21;38(1):86-97. doi: 10.1111/j.1432-1033.1973.tb03037.x.
7
Gluconeogenesis and amino acid metabolism. II. Inter-organal relations and roles of glutamine and alanine in the amino acid metabolism of fasted rats.糖异生作用与氨基酸代谢。II. 禁食大鼠氨基酸代谢中器官间的关系以及谷氨酰胺和丙氨酸的作用。
J Biochem. 1973 Nov;74(5):1003-17.
8
Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo.二氯乙酸对大鼠膈肌和心肌体外葡萄糖、丙酮酸、乙酸、3-羟基丁酸和棕榈酸代谢以及对犬心脏体内葡萄糖、乳酸、丙酮酸和游离脂肪酸摄取的影响。
Biochem J. 1973 Aug;134(4):1067-81. doi: 10.1042/bj1341067.
9
Oxidation of amino acids by diaphragms from fed and fasted rats.喂食和禁食大鼠膈肌对氨基酸的氧化作用。
Am J Physiol. 1972 Dec;223(6):1384-91. doi: 10.1152/ajplegacy.1972.223.6.1384.
10
The glucose-alanine cycle.葡萄糖-丙氨酸循环
Metabolism. 1973 Feb;22(2):179-207. doi: 10.1016/0026-0495(73)90269-2.

大鼠膈肌在体外释放丙氨酸的情况。

The release of alanine by rat diaphragm muscle in vitro.

作者信息

Snell K, Duff D A

出版信息

Biochem J. 1977 Feb 15;162(2):399-403. doi: 10.1042/bj1620399.

DOI:10.1042/bj1620399
PMID:849291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1164613/
Abstract

Alanine release by rat diaphragm muscle in vitro is stimulated by glutamate, valine, leucine and glucose. The stimulation by glutamate and valine (but not leucine) is inhibited by 3-mercaptopicolinate. These results suggest a metabolic route involving phosphoenolpyruvate carboxykinase which directs amino acid carbon skeletons towards pyruvate synthesis for alanine formation.

摘要

体外培养的大鼠膈肌释放丙氨酸受到谷氨酸、缬氨酸、亮氨酸和葡萄糖的刺激。谷氨酸和缬氨酸（而非亮氨酸）的刺激作用受到3-巯基吡啶甲酸盐的抑制。这些结果提示了一条涉及磷酸烯醇式丙酮酸羧激酶的代谢途径，该途径将氨基酸碳骨架导向丙酮酸合成以形成丙氨酸。