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大鼠膈肌中氨基酸生成丙氨酸的过程。

The formation of alanine from amino acids in diaphragm muscle of the rat.

作者信息

Goldstein L, Newsholme E A

出版信息

Biochem J. 1976 Feb 15;154(2):555-8. doi: 10.1042/bj1540555.

DOI:10.1042/bj1540555
PMID:938466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172735/
Abstract

Alanine production and pyruvate content of the isolated rat hemidiaphragm are increased by isoleucine or glutamate. These results support the hypothesis that amino acids are converted into pyruvate before oxidation and that some pyruvate is transaminated to alanine, which is released from the muscle.

摘要

异亮氨酸或谷氨酸可增加离体大鼠半膈肌的丙氨酸生成量和丙酮酸含量。这些结果支持以下假说：氨基酸在氧化之前先转化为丙酮酸，并且一些丙酮酸经转氨作用生成丙氨酸，丙氨酸从肌肉中释放出来。

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The formation of alanine from amino acids in diaphragm muscle of the rat.大鼠膈肌中氨基酸生成丙氨酸的过程。
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2
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本文引用的文献

1
OXIDATION OF AMINO ACIDS BY ISOLATED RAT DIAPHRAGM AND THE INFLUENCE OF INSULIN.大鼠离体膈肌对氨基酸的氧化作用及胰岛素的影响
Biochim Biophys Acta. 1965 Apr 12;100:295-8. doi: 10.1016/0304-4165(65)90457-5.
2
Regulation of glucose uptake by muscle. 1. The effects of insulin, anaerobiosis and cell poisons on the uptake of glucose and release of potassium by isolated rat diaphragm.肌肉对葡萄糖摄取的调节。1. 胰岛素、无氧状态及细胞毒素对离体大鼠膈肌葡萄糖摄取及钾释放的影响。
Biochem J. 1958 Nov;70(3):490-500. doi: 10.1042/bj0700490.
3
Alanine: key role in gluconeogenesis.丙氨酸：在糖异生中起关键作用。
Science. 1970 Feb 13;167(3920):1003-4. doi: 10.1126/science.167.3920.1003.
4
Oxidation of amino acids by red and white muscle fiber groups.红肌纤维和白肌纤维群对氨基酸的氧化作用。
Am J Physiol. 1974 Aug;227(2):268-72. doi: 10.1152/ajplegacy.1974.227.2.268.
5
Oxidation of amino acids by diaphragms from fed and fasted rats.喂食和禁食大鼠膈肌对氨基酸的氧化作用。
Am J Physiol. 1972 Dec;223(6):1384-91. doi: 10.1152/ajplegacy.1972.223.6.1384.
6
Protein turnover and amino acid metabolism in the regulation of gluconeogenesis.糖异生调节中的蛋白质周转与氨基酸代谢
Fed Proc. 1974 Apr;33(4):1092-7.
7
Origin and possible significance of alanine production by skeletal muscle.骨骼肌产生丙氨酸的起源及可能的意义。
J Biol Chem. 1974 Dec 10;249(23):7623-9.
8
The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase and fructose diphosphatase in muscles from vertebrates and invertebrates.脊椎动物和无脊椎动物肌肉中丙酮酸羧化酶、磷酸烯醇式丙酮酸羧化酶和果糖二磷酸酶的活性。
Biochem J. 1972 Nov;130(2):391-6. doi: 10.1042/bj1300391.
9
The activities of fructose 1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle.白色肌肉和红色肌肉中果糖1,6 - 二磷酸酶、磷酸果糖激酶和磷酸烯醇式丙酮酸羧激酶的活性。
Biochem J. 1967 May;103(2):391-9. doi: 10.1042/bj1030391.
10
Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and L-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles.肌肉对葡萄糖摄取的调节。9. 脂肪酸、酮体、四氧嘧啶糖尿病和饥饿对大鼠心脏和大鼠膈肌中丙酮酸代谢以及乳酸-丙酮酸和L-甘油3-磷酸-二羟丙酮磷酸浓度比的影响。
Biochem J. 1964 Dec;93(3):665-78. doi: 10.1042/bj0930665.