Alder J, Jarvis K, Mitten M, Shipkowitz N L, Gupta P, Clement J
Anti-Infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500.
Antimicrob Agents Chemother. 1993 Apr;37(4):864-7. doi: 10.1128/AAC.37.4.864.
Clarithromycin was shown to be effective therapy for Treponema pallidum infections in hamsters. Clarithromycin therapy was effective when initiated either 1 or 8 days after infection. The delay in initiation of therapy allowed an active infection to develop. The treponemal burden in lymph tissue of treated hamsters was eradicated, as determined by dark-field microscopy and by inoculation of lymph material into susceptible hamsters. Treatments with clarithromycin and the 14-hydroxy metabolite of clarithromycin were equally effective. Therapy with clarithromycin and penicillin was not antagonistic and did not appear to be synergistic when the two drugs were given concurrently. Pharmacokinetic evaluation of clarithromycin in hamsters showed that the doses which produced effective therapy yielded concentrations in serum similar to those routinely achieved in human sera. These findings demonstrate that clarithromycin is effective in treating active or incubating syphilis in the hamster model and could be useful in treating humans.
克拉霉素被证明是治疗仓鼠梅毒螺旋体感染的有效疗法。在感染后1天或8天开始使用克拉霉素治疗均有效。治疗开始的延迟使得活跃感染得以发展。通过暗视野显微镜检查以及将淋巴组织接种到易感仓鼠体内确定，治疗后仓鼠淋巴组织中的梅毒螺旋体负荷被根除。克拉霉素及其14 - 羟基代谢产物的治疗效果相同。当同时给予克拉霉素和青霉素时，二者之间不存在拮抗作用，也未表现出协同作用。对仓鼠体内克拉霉素的药代动力学评估表明，产生有效治疗效果的剂量在血清中产生的浓度与人类血清中通常达到的浓度相似。这些发现表明，克拉霉素在仓鼠模型中治疗活动性或潜伏性梅毒有效，可能对治疗人类梅毒有用。
