Ben-Chetrit E
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Br J Rheumatol. 1993 May;32(5):396-402. doi: 10.1093/rheumatology/32.5.396.
The SSA/Ro antigens are nuclear and cytoplasmic polypeptides which serve as autoantigens in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). They contain two major isoforms of 60 and 52 kD. The former is the native antigen while the latter is a major autoantigen in its denatured form. A third protein of 46 kD termed 'calreticulin-Ro' is an autoantigen found in the sera of some patients with SLE. However, it is probably unrelated to the SSA/Ro system. The clinical relevance of anti SSA/Ro antibodies in rheumatic diseases has also been considered. Initially these antibodies were thought to be an epiphenomenon of autoimmune diseases. Recent studies have shown that they are associated with specific clinical manifestations and disease subsets. Furthermore, animal models have demonstrated that they may enhance tissue damage. It seems that anti-SSA/Ro antibodies may play a role in the pathogenicity of SLE and SS.
SSA/Ro抗原是存在于细胞核和细胞质中的多肽，在系统性红斑狼疮（SLE）和干燥综合征（SS）中作为自身抗原。它们包含60kD和52kD两种主要的异构体。前者是天然抗原，而后者是其变性形式的主要自身抗原。第三种46kD的蛋白质称为“钙网蛋白-Ro”，是在一些SLE患者血清中发现的自身抗原。然而，它可能与SSA/Ro系统无关。抗SSA/Ro抗体在风湿性疾病中的临床相关性也已得到研究。最初，这些抗体被认为是自身免疫性疾病的一种附带现象。最近的研究表明，它们与特定的临床表现和疾病亚组相关。此外，动物模型已经证明它们可能会加重组织损伤。抗SSA/Ro抗体似乎可能在SLE和SS的发病机制中起作用。
