Wood M B, Rubin A P
Anaesthetic Department, Charing Cross Hospital, London, United Kingdom.
Anesth Analg. 1993 Jun;76(6):1274-8. doi: 10.1213/00000539-199376060-00015.
A randomized double-blind study was performed to compare ropivacaine and bupivacaine in epidural anesthesia for intraperitoneal surgery. Forty-four patients undergoing epidural anesthesia for intraperitoneal lower abdominal gynecologic surgery received 20 mL of either 1% ropivacaine or 0.75% bupivacaine via an epidural catheter. There was no difference between the two drugs in the onset, extent, and duration of sensory and motor block. Satisfactory conditions for surgery were produced in the same number of patients in each group. The cardiovascular changes and the overall incidence of adverse reactions were similar for both drugs. It is concluded that ropivacaine is an effective and safe alternative to bupivacaine when used in epidural anesthesia for lower abdominal, intraperitoneal surgery.
进行了一项随机双盲研究，比较罗哌卡因和布比卡因在腹膜内手术硬膜外麻醉中的效果。44例接受腹膜内下腹部妇科手术硬膜外麻醉的患者通过硬膜外导管接受20毫升1%罗哌卡因或0.75%布比卡因。两种药物在感觉和运动阻滞的起效时间、范围和持续时间方面没有差异。每组中相同数量的患者手术条件满意。两种药物的心血管变化和不良反应总发生率相似。得出结论，罗哌卡因用于下腹部腹膜内手术的硬膜外麻醉时，是布比卡因有效且安全的替代品。
