Tirosh E, Elhasid R, Kamah S C, Cohen A
Hannah Khoushy Child Development Center, Bnai Zion Medical Center, Haifa, Israel.
Pediatr Neurol. 1993 Mar-Apr;9(2):131-3. doi: 10.1016/0887-8994(93)90049-i.
The effects of methylphenidate in 20 children with attention-deficit disorder between the ages of 7 and 12 years were assessed in a double-blind, placebo/drug counterbalanced study. Measures of outcome included the Teacher Rating Scale and Abbreviated Parent Rating Scale: digits, words, and visual sequencing; motor control; and a maze test. The Teacher Rating Scale placebo-drug difference correlated more significantly with the outcome measures than the baseline-drug difference. The study underlines the validity of a multimeasure placebo/drug trial in evaluating the efficacy of methylphenidate in children with attention-deficit disorder.
在一项双盲、安慰剂/药物平衡研究中，评估了哌甲酯对20名年龄在7至12岁之间的注意力缺陷障碍儿童的影响。结果测量指标包括教师评定量表和简化家长评定量表：数字、单词和视觉序列；运动控制；以及迷宫测试。与基线-药物差异相比，教师评定量表的安慰剂-药物差异与结果测量指标的相关性更显著。该研究强调了多指标安慰剂/药物试验在评估哌甲酯对注意力缺陷障碍儿童疗效方面的有效性。
