Deng A Y, Gu L, Rapp J P, Szpirer C, Szpirer J
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699-0008.
Mamm Genome. 1994 Nov;5(11):712-6. doi: 10.1007/BF00426078.
Eleven rat genes have been assigned to rat chromosomes by use of mouse x rat somatic hybrids and/or use of linkage to known chromosome markers. Among them, the genes for the inducible nitric oxide synthase (Nos2) and for a vasoactive intestinal peptide receptor (Vipr) are potential candidates for genetic regulation of blood pressure and were localized to rat Chromosomes (Chrs) 10 and 8 respectively. Genes for gastric H,K-ATPase alpha subunit (Atp4a), Class I alcohol dehydrogenase (Adh), and aldolase C (Aldoc) were localized to Chrs 1, 2, and 10 respectively, and thus provide more DNA markers for genetic mapping of quantitative trait loci for blood pressure on those chromosomes. Genes for alkaline phosphatase (Alp1) and cardiac AE-3 Cl-/HCO3- exchanger (Ae3) were both localized to Chr 9. Genes for glutamate dehydrogenase (Glud) and gastric H,K-ATPase beta subunit (Atp4b) were localized to Chr 16. The ornithine decarboxylase (Odc) gene and ornithine decarboxylase pseudogene (Odcp) were localized to Chrs 6 and 11 respectively.
通过使用小鼠×大鼠体细胞杂种和/或利用与已知染色体标记的连锁关系，已将11个大鼠基因定位到大鼠染色体上。其中，诱导型一氧化氮合酶（Nos2）基因和血管活性肠肽受体（Vipr）基因是血压遗传调控的潜在候选基因，分别定位于大鼠染色体（Chrs）10和8。胃H，K - ATP酶α亚基（Atp4a）、Ⅰ类乙醇脱氢酶（Adh）和醛缩酶C（Aldoc）基因分别定位于Chrs 1、2和10，因此为这些染色体上血压数量性状位点的遗传图谱提供了更多的DNA标记。碱性磷酸酶（Alp1）基因和心脏AE - 3 Cl⁻/HCO₃⁻交换体（Ae3）基因均定位于Chr 9。谷氨酸脱氢酶（Glud）基因和胃H，K - ATP酶β亚基（Atp4b）基因定位于Chr 16。鸟氨酸脱羧酶（Odc）基因和鸟氨酸脱羧酶假基因（Odcp）分别定位于Chrs 6和11。
