Yeung R S, Taguchi T, Patriotis C, Makris A, Tsichlis P N, Levan K K, Levan G, Tartof K, Hino O, Knudson A G, Testa J R
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
Cytogenet Cell Genet. 1993;62(2-3):149-52. doi: 10.1159/000133459.
Problems in differentiating rat chromosomes 16 and 17 cytogenetically can be resolved with unique probes mapped to these chromosomes. Using somatic cell hybridization and nonisotopic in situ hybridization, probes D16FC1 and Tp12 were localized to 16p16-->p15 and 17q12.1-->q12.2, respectively. The locations of these probes can serve as reference points to facilitate mapping of future probes to rat chromosomes 16 and 17.
利用定位到这些染色体上的独特探针，可以解决在细胞遗传学上区分大鼠16号和17号染色体的问题。通过体细胞杂交和非同位素原位杂交，探针D16FC1和Tp12分别定位于16p16→p15和17q12.1→q12.2。这些探针的定位可作为参考点，以促进未来探针在大鼠16号和17号染色体上的定位。
