Swartzberg J E, Maresca R M, Remington J S
J Infect Dis. 1977 Mar;135 Suppl:S99-103. doi: 10.1093/infdis/135.supplement.s99.
The incidence of and factors associated with diarrhea were evaluated in 1,000 patients receiving clindamycin. Diarrhea occurred in 6.6% of the patients, and of the many parameters evaluated, a significant association with diarrhea was found only for age (higher incidence in patients older than 20 years), sex (higher incidence in females), and route of administration (higher incidence with oral than with parenteral administration). It is of interest that we were unable to find a positive correlation between dose of drug or duration of therapy and diarrhea. Diarrhea began within 48 hr of start of clindamycin therapy in 52.3% of the patients and within five days of therapy in 75.3%. Nineteen patients developed diarrhea after they had stopped receiving the drug. Duration of diarrhea varied considerably, with a mean of 11.4 days and a range of one to 120 days.
对1000名接受克林霉素治疗的患者的腹泻发生率及相关因素进行了评估。6.6%的患者出现腹泻，在评估的众多参数中，仅发现年龄（20岁以上患者发生率较高）、性别（女性发生率较高）和给药途径（口服给药比胃肠外给药发生率高）与腹泻有显著关联。有趣的是，我们未能发现药物剂量或治疗持续时间与腹泻之间存在正相关。52.3%的患者在克林霉素治疗开始后48小时内出现腹泻，75.3%的患者在治疗五天内出现腹泻。19名患者在停药后出现腹泻。腹泻持续时间差异很大，平均为11.4天，范围为1至120天。
