Swartzberg J E, Maresca R M, Remington J S
Arch Intern Med. 1976 Aug;136(8):876-9.
The incidience and parameters associated with diarrhea related to clindamycin usage were studied in a population of both inpatients and outpatients. Diarrhea occurred in 66 (6.6%) of the 1,000 patients. In three of them, substantial morbidity was associated with the diarrhea. Of the multiple parameters that were evaluated, significant association with diarrhea was found only for age (patients over the age of 20 years) (P less than .01) and sex (females) (P less than .005). Interestingly, dose, duration, and route of administration showed no significant relationship to diarrhea (P greater than .05).
在住院患者和门诊患者群体中，研究了与克林霉素使用相关的腹泻发生率及相关参数。1000名患者中有66名（6.6%）出现腹泻。其中3人因腹泻出现严重发病情况。在评估的多个参数中，仅发现年龄（20岁以上患者）（P小于0.01）和性别（女性）（P小于0.005）与腹泻有显著关联。有趣的是，剂量、用药时长和给药途径与腹泻无显著关系（P大于0.05）。
