类志贺邻单胞菌溶血活性的表达
Expression of hemolytic activity by Plesiomonas shigelloides.
作者信息
Janda J M, Abbott S L
机构信息
Microbial Diseases Laboratory, California Department of Health Services, Berkeley 94704-1011.
出版信息
J Clin Microbiol. 1993 May;31(5):1206-8. doi: 10.1128/jcm.31.5.1206-1208.1993.
Abstract
More than 90% of the Plesiomonas shigelloides strains that we tested produced a beta-hemolysin, as judged by the results of agar overlay and contact-dependent hemolysis assays. The hemolysin was cell associated, was active against the erythrocytes of various animal species, and was synthesized at both 25 and 35 degrees C. Activity was lost after thermal or proteolytic treatments or after preincubation in the presence of gentamicin; hemolytic activity did not appear to correlate with the previously established 50% lethal doses for seven of these strains. The hemolysin may play a role in iron acquisition in vivo via the lysis of erythrocytes, liberating hemoglobin, or, alternatively, may be involved in gastrointestinal disease.
摘要
通过琼脂覆盖法和接触依赖性溶血试验的结果判断，我们检测的超过90%的类志贺邻单胞菌菌株产生β-溶血素。该溶血素与细胞相关，对多种动物物种的红细胞有活性，并且在25℃和35℃时均能合成。经过热处理或蛋白水解处理后，或在庆大霉素存在下预孵育后，活性丧失；溶血活性似乎与其中7个菌株先前确定的50%致死剂量无关。溶血素可能通过红细胞裂解在体内获取铁的过程中发挥作用，释放血红蛋白，或者可能参与胃肠道疾病。
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