Danchin N, Retournay G, Stchepinsky O, Selton-Suty C, Voiriot P, Hoen B, Canton P, Villemot J P, Mathieu P, Cherrier F
Service de Cardiologie, CHU Nancy-Brabois, 54500 Vandoeuvre-lès-Nancy, France.
Heart. 1999 Feb;81(2):177-81. doi: 10.1136/hrt.81.2.177.
To assess the long term prognostic significance of aortic valve ring abscess in patients with aortic endocarditis.
A consecutive series of 75 patients who had surgery for aortic infective endocarditis between 1981 and 1989; 35 had aortic ring abscesses (group 1) and 40 did not (group 2). Mean age did not differ between the two groups. Prosthetic valve endocarditis was present in 17% of group 1 and 5% of group 2. Pneumococcal or beta haemolytic streptococcal endocarditis was more common in patients with native valve endocarditis who had aortic ring abscesses (20% v 5%).
Cohort analysis.
In-hospital mortality (11.4% v 7.5%) and 10 year survival (56% v 66%) were not significantly different between groups 1 and 2. In patients with native valve endocarditis, 10 year survival was 62% and 66%, respectively for patients with or without ring abscess, and 10 year reintervention-free survival was 38% v 58% (p = 0.11). In these patients, the presence of an intercurrent illness, severe congestive heart failure before surgery, and use of valved conduits for surgical treatment were predictors of poorer long term survival. At follow up residual aortic regurgitation was documented in 72% of patients in group 1 and 26% in group 2 (p < 0.01).
Aortic valve ring abscess is not an independent marker of poor long term outcome in patients with infective endocarditis. However, as residual aortic regurgitation appears frequent at follow up, specific surgical techniques should be considered in patients with paravalvar abscesses.
评估主动脉瓣环脓肿对主动脉心内膜炎患者的长期预后意义。
1981年至1989年间连续75例接受主动脉感染性心内膜炎手术的患者;35例有主动脉瓣环脓肿(第1组),40例无(第2组)。两组平均年龄无差异。第1组17%存在人工瓣膜心内膜炎,第2组为5%。肺炎球菌或β溶血性链球菌心内膜炎在有主动脉瓣环脓肿的天然瓣膜心内膜炎患者中更常见(20%对5%)。
队列分析。
第1组和第2组的住院死亡率(11.4%对7.5%)和10年生存率(56%对66%)无显著差异。在天然瓣膜心内膜炎患者中,有或无瓣环脓肿患者的10年生存率分别为62%和66%,10年无再次干预生存率为38%对58%(p = 0.11)。在这些患者中,并发疾病的存在、术前严重充血性心力衰竭以及使用带瓣管道进行手术治疗是长期生存率较差的预测因素。随访时,第1组72%的患者记录有残余主动脉反流,第2组为26%(p < 0.01)。
主动脉瓣环脓肿并非感染性心内膜炎患者长期预后不良的独立标志物。然而,由于随访时残余主动脉反流似乎很常见,对于有瓣周脓肿的患者应考虑采用特定的手术技术。