Basso A, Fernández A, Althabe O, Sabini G, Piriz H, Belitzky R
Obstet Gynecol. 1977 May;49(5):628-31.
Ten pregnant women and three pregnant sheep received mannitol intravenously. The results show that during late pregnancy this substance appears in amniotic fluid, and when the fetus is alive, its concentration increases with time, reaching values which are higher than those simultaneously obtained in maternal plasma. The experiments performed in sheep show that in fetal urine the concentration of mannitol reached values 10 to 20 times higher than those found in fetal plasma. This supports the hypothesis that the fetal kidney has an important role in the transference of this type of substance from the mother to the amniotic fluid.
十名孕妇和三只怀孕的绵羊接受了静脉注射甘露醇。结果显示，在妊娠晚期，这种物质会出现在羊水中，并且当胎儿存活时，其浓度会随时间增加，达到高于同时在母体血浆中测得的值。在绵羊身上进行的实验表明，胎儿尿液中甘露醇的浓度比胎儿血浆中的浓度高出10至20倍。这支持了胎儿肾脏在将这类物质从母体转移至羊水过程中起重要作用的假说。
