Ewertz M
Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen.
APMIS Suppl. 1993;33:99-106.
Survival from breast cancer was examined in approximately 76,000 women and 600 men diagnosed in Denmark between 1943 and 1987. About 5% of patients mainly known from death certificates only were excluded from the analysis. Overall, survival improved with time, the relative five-year survival rates increasing from 47 to 69% in women and from 40 to 58% in men. Women had significantly better survival than men. Age at diagnosis was a prognostic factor in women as well as in men, the survival rates decreasing with increasing age at diagnosis. This age effect persisted after stratification for extent of disease. Although it was not demonstrated that the proportion of early-stage breast cancers increased with time, the improvement in survival may be related to increased diagnostic activity. The introduction of adjuvant breast cancer therapy has also improved survival, particularly among women aged less than 45.
对1943年至1987年间在丹麦确诊的约76,000名女性和600名男性的乳腺癌生存情况进行了研究。约5%的患者仅从死亡证明中得知，这些患者被排除在分析之外。总体而言，生存率随时间提高，女性的相对五年生存率从47%提高到69%，男性从40%提高到58%。女性的生存率显著高于男性。诊断时的年龄是女性和男性的一个预后因素，生存率随着诊断时年龄的增加而降低。在按疾病范围分层后，这种年龄效应仍然存在。虽然没有证明早期乳腺癌的比例随时间增加，但生存率的提高可能与诊断活动的增加有关。辅助性乳腺癌治疗的引入也提高了生存率，特别是在年龄小于45岁的女性中。
